Modeling and simulation of breakthrough curves during purification of two chitosanases from Metarhizium anisopliae using ion-exchange with expanded bed adsorption chromatography

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dc.contributor.authorSantos, Everaldo Silvino dos
dc.contributor.authorSantana, Sergio Carvalho de
dc.contributor.authorSilva Filho, Raimundo Cosme da
dc.contributor.authorCavalcanti, Jorge dos Santos
dc.contributor.authorOliveira, Jackson Araujo de
dc.contributor.authorMacedo, Gorete Ribeiro de
dc.contributor.authorPadilha, Francine Ferreira
dc.date.accessioned2021-05-17T13:24:31Z
dc.date.available2021-05-17T13:24:31Z
dc.date.issued2014-02-17
dc.description.resumoA mathematical model was developed to predict breakthrough curves during purification of the two chitosan- ases from Metarhizium anisopliae by expanded bed adsorption, taking into account the axial dispersion of liquid and using Streamline DEAE and SP XL adsorbents, anion and cation exchange resins, respectively. All the experiments were performed without clarification (with cells) aiming at the reduction of unit operations in future projects of separation processes, thereby reducing capital and operating costs. Chitosanases are enzymes that hydrolyze the carbohydrate chitosan, resulting in oligosaccharides that have many remarkable biological activities, such as anti-cancer, anti-HIV and antioxidant activities. The two adsorbents had similar performance in relation to hydrodynamics and mass transfer. The results of the parametric sensitivity analysis agree with the literature, and the model was validated with an average high degree of fit (94.68%) between simulated and experimental data obtained in this workpt_BR
dc.identifier.citationSantana, S. C. ; SILVA FILHO, R. C. ; CAVALCANTI, J. S. ; OLIVEIRA, J. A. ; Macedo, Gorete R. ; Padilha, F. F ; SANTOS, E. S. . Modeling and simulation of breakthrough curves during purification of two chitosanases from Metarhizium anisopliae using ion-exchange with expanded bed adsorption chromatography. Korean Journal of Chemical Engineering (Print), v. 31, p. 684-691, 2014. Disponível em: https://link.springer.com/article/10.1007%2Fs11814-013-0269-3 Acesso em: 06 abr. 2021. https://doi.org/10.1007/s11814-013-0269-3pt_BR
dc.identifier.doi10.1007/s11814-013-0269-3
dc.identifier.issn0256-1115
dc.identifier.issn1975-7220
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/32529
dc.languageenpt_BR
dc.publisherSpringer Nature Switzerlandpt_BR
dc.rightsAttribution-NonCommercial 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/br/*
dc.subjectModelingpt_BR
dc.subjectExpanded Bed Adsorptionpt_BR
dc.subjectPurificationpt_BR
dc.subjectChitosanasept_BR
dc.subjectMetarhizium anisopliaept_BR
dc.titleModeling and simulation of breakthrough curves during purification of two chitosanases from Metarhizium anisopliae using ion-exchange with expanded bed adsorption chromatographypt_BR
dc.typearticlept_BR

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