Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

Dakic, Vanja; Nascimento, Juliana Minardi; Sartore, Rafaela Costa; Maciel, Renata de Moraes; Araújo, Dráulio Barros de; Ribeiro, Sidarta Tollendal Gomes; Martins-de-Souza, Daniel; Rehen, Stevens K.

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

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dc.contributor.author	Dakic, Vanja
dc.contributor.author	Nascimento, Juliana Minardi
dc.contributor.author	Sartore, Rafaela Costa
dc.contributor.author	Maciel, Renata de Moraes
dc.contributor.author	Araújo, Dráulio Barros de
dc.contributor.author	Ribeiro, Sidarta Tollendal Gomes
dc.contributor.author	Martins-de-Souza, Daniel
dc.contributor.author	Rehen, Stevens K.
dc.date.accessioned	2017-10-11T15:26:28Z
dc.date.available	2017-10-11T15:26:28Z
dc.date.issued	2017-10-09
dc.description.resumo	Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, antidepressant effects, and changes in brain areas related to attention. Legal restrictions and the lack of adequate experimental models have limited the understanding of how such substances impact human brain metabolism. Here we used shotgun mass spectrometry to explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids. Out of the 6,728 identified proteins, 934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids. In silico analysis reinforced previously reported anti-inflammatory actions of 5-MeO-DMT and revealed modulatory effects on proteins associated with long-term potentiation, the formation of dendritic spines, including those involved in cellular protrusion formation, microtubule dynamics, and cytoskeletal reorganization. Our data offer the first insight about molecular alterations caused by 5-MeO-DMT in human cerebral organoids.	pt_BR
dc.identifier.citation	DAKIC, V. et al. Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Scietific reports, [s. l.], v. 7, p.12863, out./2017.	pt_BR
dc.identifier.doi	10.1038/s41598-017-12779-5
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/24038
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	5-MeO-DMT	pt_BR
dc.subject	Neural stem cells	pt_BR
dc.subject	Cellular neuroscience	pt_BR
dc.subject	Neuroscience	pt_BR
dc.subject	Proteomics	pt_BR
dc.title	Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT	pt_BR
dc.type	article	pt_BR