Effects of 5 % weight loss through diet or diet plus exercise on cardiovascular parameters of obese: a randomized clinical trial

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dc.contributor.authorFayh, Ana Paula Trussardi
dc.contributor.authorLopes, André Luiz
dc.contributor.authorSilva, Antônio Marcos Vargas da
dc.contributor.authorReischak-Oliveira, Álvaro
dc.contributor.authorFriedman, Rogério
dc.date.accessioned2023-12-14T23:59:52Z
dc.date.available2023-12-14T23:59:52Z
dc.date.issued2013
dc.description.resumoObjective: To evaluate the effects of 5 % weight loss, through diet only or diet plus exercise, on lipid profile, inflammation and endothelial function in obese individuals. Methods: In this randomized clinical trial, 48 obese individuals were randomized to either a diet only group (DI) or a diet and exercise group (DI + EXE). Treatment was maintained until 5 % of the initial body weight was lost. At baseline and upon completion, the following parameters were analyzed: total cholesterol and fractions, triglycerides, fibrinogen, von Willebrand factor, high-sensitive C-reactive protein (hs-CRP) and endothelial function (brachial artery flow-mediated vasodilation—FMD). Results: Thirteen individuals dropped out before completing the weight loss intervention. The median time required for reduction of 5 % of initial body weight was 79.7 days for the DI group and 65.9 days for the DI + EXE group (P = 0.16). In both DI (n = 18) and DI + EXE (n = 17), total cholesterol (−15.8 ± 4.8 and −10.5 ± 4.9 mg/dL, respectively), triglycerides (−33.8 ± 10.0 and −39.4 ± 10.3 mg/dL, respectively) and hs-CRP (−1.35 ± 0.41 and −0.45 ± 0.43 mg/L, respectively) decreased significantly, and in a similar response (repeated measures ANOVA). Weight loss did not change significantly the fibrinogen and FMD in both groups. Conclusion: A 5 % weight loss improves lipid profile and reduces inflammation in obese individuals. Endothelial function did not change significantly. Weight loss has a significant impact on these cardiovascular risk factors, and this is independent of physical trainingpt_BR
dc.identifier.citationFAYH, Ana Paula Trussardi; LOPES, André Luiz; SILVA, Antônio Marcos Vargas da; REISCHAK-OLIVEIRA, Álvaro; FRIEDMAN, Rogério. Effects of 5 % weight loss through diet or diet plus exercise on cardiovascular parameters of obese: a randomized clinical trial. European Journal of Nutrition, [S.l.], v. 52, p. 1443-1450, 2013. DOI: 10.1007/s00394-012-0450-1. Disponível em: 10.1007/s00394-012-0450-1. Disponível em: https://link.springer.com/article/10.1007/s00394-012-0450-1. Acesso em: 14 dez. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00394-012-0450-1
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/55965
dc.languageenpt_BR
dc.publisherEuropean Journal of Nutritionpt_BR
dc.subjectObesitypt_BR
dc.subjectlipid profilept_BR
dc.subjectinflammationpt_BR
dc.subjectdietpt_BR
dc.subjectexercisept_BR
dc.titleEffects of 5 % weight loss through diet or diet plus exercise on cardiovascular parameters of obese: a randomized clinical trialpt_BR
dc.typearticlept_BR

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