Assessment of acute toxicity of crude extract rich in carotenoids from Cantaloupe melon (Cucumis melo L.) and the gelatin-based nanoparticles using the zebrafish (Danio rerio) model

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dc.contributor.authorMaia, Juliana Kelly da Silva
dc.contributor.authorPais, Tatiana dos Santos
dc.contributor.authorLuchiari, Ana Carolina
dc.contributor.authorSouza, Augusto Monteiro de
dc.contributor.authorMedeiros, Isaiane
dc.contributor.authorSilva, Maria Gabriela Ferreira Rocha
dc.contributor.authorSantos, Yohanna Layssa dos
dc.contributor.authorPassos, Thaís Souza
dc.contributor.authorMorais, Ana Heloneida de Araújo
dc.date.accessioned2024-08-12T19:14:56Z
dc.date.available2024-08-12T19:14:56Z
dc.date.issued2023-11
dc.description.resumoCantaloupe melon is known for its carotenoid-rich orange pulp. However, carotenoids are sensitive to oxygen, light, and heat, potentially reducing their benefits. Nanoencapsulation can preserve these benefits but raises concerns about toxicity. We aimed to assess the safety and bioactive potential of crude extract-rich carotenoids (CE) and nanoparticles based on gelatin loaded with CE (EPG) by investigating parameters such as cardio or neurotoxicity, especially acute toxicity. EPG was obtained by O/W emulsification and characterized by different methods. Zebrafish embryos were exposed to CE and EPG at 12.5 mg/L and 50 mg/L for 96h and were investigated for survival, hatching, malformations, and seven days post fertilization (dpf) larvae’s visual motor response. Adult fish underwent behavioral tests after acute exposure of 96h. CE and EPG showed no acute toxicity in zebrafish embryos, and both improved the visual motor response in 7dpf larvae (p = 0.01), suggesting the potential antioxidant and provitamin A effect of carotenoids in cognitive function and response in the evaluated model. Adult fish behavior remained with no signs of anxiety, stress, swimming pattern changes, or sociability that would indicate toxicity. This study highlights the safety and potential benefits of carotenoids in zebrafish. Further research is needed to explore underlying mechanisms and long-term effectspt_BR
dc.identifier.citationPAIS, Tatiana dos Santos; LUCHIARI, Ana Carolina; SOUZA, Augusto Monteiro de et al. Assessment of acute toxicity of crude extract rich in carotenoids from Cantaloupe melon (Cucumis melo L.) and the gelatin-based nanoparticles using the zebrafish (Danio rerio) model. Food and Chemical Toxicology, [S.l.], v. 181, p. 1-12, nov. 2023. DOI: 10.1016/j.fct.2023.114091. Disponível em: https://www.sciencedirect.com/science/article/pii/S0278691523004933?via%3Dihub. Acesso em: 8 mai. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1016/j.fct.2023.114091
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/59142
dc.languageenpt_BR
dc.publisherFood and Chemical Toxicologypt_BR
dc.subjectNatural pigmentspt_BR
dc.subjectNanoencapsulationpt_BR
dc.subjectPreclinical modelpt_BR
dc.subjectEmbryotoxicitypt_BR
dc.subjectVisual motor responsept_BR
dc.titleAssessment of acute toxicity of crude extract rich in carotenoids from Cantaloupe melon (Cucumis melo L.) and the gelatin-based nanoparticles using the zebrafish (Danio rerio) modelpt_BR
dc.typearticlept_BR

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