ATM, BCL2, and TGFb gene polymorphisms as radiotherapy outcome biomarkers in head and neck squamous cell carcinoma patients

Agostini, Lidiane Pignaton; Stur, Elaine; Garcia, Fernanda M.; Ventorim, Diego P.; Reis, Raquel S. dos; Dettogni, Raquel S.; Santos, Eldamária V. W. dos; Peterle, Gabriela T.; Maia, Lucas L.; Mendes, Suzanny O.; Carvalho, Marcos B. de; Tajara, Eloiza H.; Paula, Flavia de; Santos, Marcelo dos; Silva, Adriana M. A. da; Louro, Iúri Drumond

ATM, BCL2, and TGFb gene polymorphisms as radiotherapy outcome biomarkers in head and neck squamous cell carcinoma patients

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dc.contributor.author	Agostini, Lidiane Pignaton
dc.contributor.author	Stur, Elaine
dc.contributor.author	Garcia, Fernanda M.
dc.contributor.author	Ventorim, Diego P.
dc.contributor.author	Reis, Raquel S. dos
dc.contributor.author	Dettogni, Raquel S.
dc.contributor.author	Santos, Eldamária V. W. dos
dc.contributor.author	Peterle, Gabriela T.
dc.contributor.author	Maia, Lucas L.
dc.contributor.author	Mendes, Suzanny O.
dc.contributor.author	Carvalho, Marcos B. de
dc.contributor.author	Tajara, Eloiza H.
dc.contributor.author	Paula, Flavia de
dc.contributor.author	Santos, Marcelo dos
dc.contributor.author	Silva, Adriana M. A. da
dc.contributor.author	Louro, Iúri Drumond
dc.date.accessioned	2021-02-03T11:41:13Z
dc.date.available	2021-02-03T11:41:13Z
dc.date.issued	2017-12
dc.description.resumo	Aims: Polymorphisms in cell cycle genes are considered prognostic as radiosensitivity markers in patients with head and neck squamous cell carcinoma. Therefore, we aimed to investigate the relationship of ATM 5557G>A, ATM IVS62 + 60G>A, TP53 215G>C, BCL2-938C>A, TGFb-509C>T, and TGFb 29C>T with radiotherapy response. Materials and Methods: Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism in 210 patients with oral cavity/oropharyngeal carcinoma and 101 patients with laryngeal tumors. Results: In irradiated oral cavity/oropharyngeal tumors, the ATM IVS62 + 60G>A AA genotype significantly increased local recurrence risk (odds ratio [OR] = 4.43; confidence interval [CI] = 1.22–16.13) and the BCL2- 938C>A C allele and the TGFb-509C>T T allele were associated with worse disease-specific survival (hazar dratio [HR] = 0.46; CI = 0.24–0.90 and HR = 2.20; CI = 1.12–4.29, respectively). In irradiated laryngeal carcinoma, the TGFb 29C>T C allele was associated with increased local recurrence risk (OR = 0.09; CI = 0.02–0.53), death rate (OR = 0.18; CI = 0.04–0.86), and worse local disease-free and disease-specific survival rates (HR = 0.13; CI = 0.03–0.59 and HR = 0.21; CI = 0.07–0.60, respectively), while the BCL2-938C>A C allele was related to a worse disease-specific survival (HR = 0.32; CI = 0.12–0.83). Discussion: These results can help individualize treatment according to a patient’s genetic markers. We demonstrated that ATM IVS62 + 60G>A, TGFb 29C>T, TGFb-509C>T, and BCL2-938C>A can function as biomarkers of tumor radiosensitivity, being candidates for a predictive genetic profile of radiotherapy response	pt_BR
dc.identifier.citation	AGOSTINI, Lidiane Pignaton et al. ATM, BCL2, and TGFβ Gene Polymorphisms as Radiotherapy Outcome Biomarkers in Head and Neck Squamous Cell Carcinoma Patients. Genetic Testing And Molecular Biomarkers, [s.l.], v. 21, n. 12, p. 727-735, dez. 2017. Mary Ann Liebert Inc. Disponível em: https://www.liebertpub.com/doi/10.1089/gtmb.2017.0180. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1089/gtmb.2017.0180.	pt_BR
dc.identifier.doi	10.1089/gtmb.2017.0180
dc.identifier.issn	1945-0257 (online)
dc.identifier.issn	1945-0265 (print)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31363
dc.language	en	pt_BR
dc.publisher	Mary Ann Liebert	pt_BR
dc.rights	Attribution-NonCommercial 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc/3.0/br/	*
dc.subject	Head and neck squamous cell carcinoma	pt_BR
dc.subject	Oral cavity/oropharynx	pt_BR
dc.subject	Larynx	pt_BR
dc.subject	Radiosensitivity	pt_BR
dc.subject	Polymorphisms	pt_BR
dc.title	ATM, BCL2, and TGFb gene polymorphisms as radiotherapy outcome biomarkers in head and neck squamous cell carcinoma patients	pt_BR
dc.type	article	pt_BR