α-Tocopherol supplementation avoids apoptosis in the anal sphincter

Página do item simplificado Estatísticas
dc.contributor.authorCorrea, Romualdo da Silva
dc.contributor.authorReis, Leonardo Oliveira
dc.contributor.authorLorenzetti, Fábio
dc.contributor.authorPalma, Paulo
dc.contributor.authorOrtiz, Valdemar
dc.contributor.authorDambros, Miriam
dc.date.accessioned2023-07-06T18:29:59Z
dc.date.available2023-07-06T18:29:59Z
dc.date.issued2011-08-18
dc.description.resumoPurpose: To analyze the influence of α-tocopherol supplementation on the levels of oxidative stress and apoptosis rates in the anal sphincter induced by orchiectomy in rats. Methods: Forty male Wistar rats weighing 250–300 g, were divided into four groups and sacrificed 8 weeks after: I– Control: sham; II– Orchiectomy: bilateral orchiectomy; III– Pre Orchiectomy Tocopherol: α-tocopherol supplementation for 4 weeks preceding bilateral orchiectomy; IV– Orchiectomy Full Tocopherol: α-tocopherol supplementation for 4 weeks before and 8 weeks after bilateral orchiectomy. The anal sphincter was analyzed stereologically to evaluate the density of collagen and the muscle fibers. The oxidative stress and the apoptosis were determined with 8-isprostane and caspase-3, respectively. Results: The collagen fibers concentration was statistically greater in Orchiectomy group than the others. The muscle fibers concentration was higher in Control and Orchiectomy Full Tocopherol than Orchiectomy and Pre Orchiectomy Tocopherol groups. Orchiectomy group showed higher 8-isoprostane concentrations compared to the other groups (p < 0.0003). Pre Orchiectomy Tocopherol and Orchiectomy Full Tocopherol groups presented caspase-3 levels lower than the Orchiectomy group (0.0072). Conclusion: Vitamin supplementation with α-tocopherol for 12 weeks had the highest protection against bilateral orchiectomy generation of reactive oxygen species as well as apoptosis in the muscle fibers of the anal sphincter of rats.pt_BR
dc.identifier.citationCORREA, Romualdo da Silva; REIS, Leonardo Oliveira; LORENZETTI, Fábio; PALMA, Paulo; ORTIZ, Valdemar; DAMBROS, Miriam. α-Tocopherol supplementation avoids apoptosis in the anal sphincter. The Aging Male, [S.L.], v. 15, n. 1, p. 48-53, 18 ago. 2011. Informa UK Limited. http://dx.doi.org/10.3109/13685538.2011.593657. Disponível em: https://www.tandfonline.com/doi/full/10.3109/13685538.2011.593657. Acesso em: 05 jul. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.3109/13685538.2011.593657
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/53103
dc.languageenpt_BR
dc.publisherTaylor and Francispt_BR
dc.subjectapoptosispt_BR
dc.subjectanal sphincterpt_BR
dc.subjectalpha-tocopherolpt_BR
dc.subjectoxidative stresspt_BR
dc.subjectantioxidants, vitaminspt_BR
dc.titleα-Tocopherol supplementation avoids apoptosis in the anal sphincterpt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
TocopherolSupplementationAvoids_Correa_Etal_2011.pdf
Tamanho:
997.6 KB
Formato:
Adobe Portable Document Format
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

CCS - DMI - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM