OLMα2 cells bidirectionally modulate learning

Siwani, Samer; França, Arthur S. C.; Mikulovic, Sanja; Reis, Amilcar; Hilscher, Markus M.; Edwards, Steven J.; Leão, Richardson Naves; Tort, Adriano Bretanha Lopes; Kullander, Klas

OLMα2 cells bidirectionally modulate learning

Página do item simplificado Estatísticas

dc.contributor.author	Siwani, Samer
dc.contributor.author	França, Arthur S. C.
dc.contributor.author	Mikulovic, Sanja
dc.contributor.author	Reis, Amilcar
dc.contributor.author	Hilscher, Markus M.
dc.contributor.author	Edwards, Steven J.
dc.contributor.author	Leão, Richardson Naves
dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.contributor.author	Kullander, Klas
dc.date.accessioned	2018-07-11T16:30:36Z
dc.date.available	2018-07-11T16:30:36Z
dc.date.issued	2018-07
dc.description.resumo	Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor α2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLMα2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLMα2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLMα2 cell activation inhibits fear-related memories and that OLMα2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLMα2 cells are an important component in the CA1 microcircuit regulating learning and memory processes.	pt_BR
dc.identifier.citation	SIWANI, S. et al. OLMa2 cells bidirectionally modulate learning, Neuron, v. 99, n.1, jul./2018.	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.neuron.2018.06.022
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/25586
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	OLM cells	pt_BR
dc.subject	object recognition	pt_BR
dc.subject	passive inhibitory avoidance	pt_BR
dc.subject	memory	pt_BR
dc.title	OLMα2 cells bidirectionally modulate learning	pt_BR
dc.type	article	pt_BR