Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/jspui/handle/1/2952
Título: Procoagulant state after raloxifene therapy in postmenopausal women
Autor(es): Azevedo, George Dantas de
Franco, Rendrik França
Baggio, Márcia Sueli
Maranhão, Técia Maria de Oliveira
Sá, Marcos Felipe Silva de
Palavras-chave: Climacteric;Hemostatic system;Raloxifene;SERMs;Selective Estrogen Receptor Modulators;Postmenopausal women;Moduladores Seletivos de Receptor Estrogênico
Data do documento: 2005
Citação: AZEVEDO, G. D.; FRANCO, R. F.; BAGGIO, M. S.; MARANHÂO, T. M. O.; SÁ, M. F. S. ( 2005)
Resumo: Objective: To investigate the effects of raloxifene on the hemostatic system in postmenopausal women. Design: A prospective longitudinal study. Setting: Outpatient clinic of the Faculty of Medicine of Ribeirão Preto, Brazil. Patient(s): Sixteen postmenopausal women aged 56.8 5.9 years (mean SD). Intervention(s): Raloxifene hydrochloride (60 mg once daily) was administered orally for a period of 6 months. Main Outcome Measure(s): Plasma activities of coagulation factors (II, V, VII, VIII, IX, X, XI, XII, and fibrinogen), prothrombin-derived fragment 1 2, and activated protein C (APC) sensitivity ratio were measured at baseline and after 1, 3, and 6 months of treatment. Result(s): Factor VIII activity increased by 17.1% and 26.9% at 3 and 6 months of treatment, respectively, compared with baseline. Factor XI and FXII activities significantly increased by 10.9% and 43.1%, respectively, after 6 months compared with baseline. A significant reduction of APC sensitivity ratio also was observed after 6 months of treatment. Conclusion(s): A procoagulant state characterized by increased factor VIII, XI, and XII plasma levels and by reduced APC sensitivity was observed after raloxifene therapy in post-menopausal women
Descrição: AZEVEDO, George Dantas de et al. Procoagulant state after raloxifene therapy in postmenopausal women. Fertility and Sterility, Estados Unidos, v.84, n.6, p.1680-1684, 2005
URI: http://repositorio.ufrn.br:8080/jspui/handle/1/2952
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