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https://repositorio.ufrn.br/jspui/handle/123456789/20701| Título: | Radiological Characterization of Cerebral Phenotype in Newborn Microcephaly Cases from 2015 Outbreak in Brazil |
| Título(s) alternativo(s): | Radiological Characterization of Cerebral Phenotype in Newborn Microcephaly Cases from 2015 Outbreak in Brazil |
| Autor(es): | Rocha, Yuri Raoni Ramalho Costa, José Ricardo Cavalcanti Costa, Pericles Almeida Maia, Gessica Vasconcelos, Rafael de Medeiros Tejo, Cynthia Ramos Batista, Rafaella Martins Lima Neto, Manoel Lima, Gustavo Graco Martins de Negromonte, Francisco Borba, Marcelle Jeronimo, Selma Maria Bezerra Sequerra, Eduardo Bouth |
| Palavras-chave: | Brazil;Zika virus;Computed tomography;Microcephaly;Outbreak |
| Data do documento: | 8-Jun-2016 |
| Referência: | Ramalho Rocha YR, Cavalcanti Costa JR, Almeida Costa P, Maia G, Vasconcelos RdM, Ramos Tejo C, Martins Batista R, Lima Neto M, Martins de Lima GG, Negromonte F, Borba M, Bezerra Jeronimo SM, Sequerra EB, Moreira Neto M. Radiological Characterization of Cerebral Phenotype in Newborn Microcephaly Cases from 2015 Outbreak in Brazil. PLOS Currents Outbreaks. 2016 Jun 8 . Edition 1. doi: 10.1371/currents.outbreaks.e854dbf51b8075431a05b39042c00244. |
| Abstract: | Introduction: Brazil is facing, since October of 2015, an outbreak of microcephalic fetuses. This outbreak is correlated with the beginning of circulation of Zika virus (ZIKV) in the country. Although it is clear that the size of the head is diminished in these fetuses, the brain phenotype associated with these malformations is unknown. Methods: We collected computed tomography images of the microcephaly cases from the region of Natal, Rio Grande do Norte, from September 2015 to February 2016. Findings: The microcephalies derived from the current outbreak are associated with intracerebral calcifications, malformation of the ventricular system, migratory disorders in the telencephalon and, in a lower frequency, malformation of the cerebellum and brainstem. Discussion: The characteristics described herein are not usually found in other types of microcephaly. We suggest that this work can be used as a guideline to identify microcephaly cases associated to the current outbreak. |
| Resumo: | Introduction: Brazil is facing, since October of 2015, an outbreak of microcephalic fetuses. This outbreak is correlated with the beginning of circulation of Zika virus (ZIKV) in the country. Although it is clear that the size of the head is diminished in these fetuses, the brain phenotype associated with these malformations is unknown. Methods: We collected computed tomography images of the microcephaly cases from the region of Natal, Rio Grande do Norte, from September 2015 to February 2016. Findings: The microcephalies derived from the current outbreak are associated with intracerebral calcifications, malformation of the ventricular system, migratory disorders in the telencephalon and, in a lower frequency, malformation of the cerebellum and brainstem. Discussion: The characteristics described herein are not usually found in other types of microcephaly. We suggest that this work can be used as a guideline to identify microcephaly cases associated to the current outbreak. |
| URI: | http://repositorio.ufrn.br/handle/123456789/20701 |
| Aparece nas coleções: | ICe - Artigos publicados em periódicos |
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