Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/jspui/handle/123456789/21200
Title: Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study
Authors: Pereira, Joabe dos Santos
Fontes, Fabrícia Lima
Medeiros, Sílvia Regina Batistuzzo de
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Miguel, Marcia Cristina da Costa
Keywords: DNA repair;Genetic polymorphisms;Oral cancer;Restriction fragment length polymorphisms;Squamous cell carcinoma
Issue Date: 2016
Citation: PEREIRA, Joabe dos Santos et al. Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study. Archives of Oral Biology , v. 64, p. 19-23, 2016.
Portuguese Abstract: Objective to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC). Design the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results XPD-Lys/Gln was more common in IFH (n = 28; 70%) than in OSCC (n = 24; 44.4%) (OR: 0.3; p < 0.05). XPD-Gln was more frequent in high-grade lesions (0.48) than in low-grade lesions (0.21) (OR: 3.4; p < 0.05). The Gln/Gln genotype was associated with III and IV clinical stages (OR: 0.07; p < 0.05). XRCC3-Met was more frequent in OSCC (0.49) than in IFH (0.35) (OR: 2.6; p < 0.05). The Met/Met genotype was associated with the presence of metastases (OR: 8.1; p < 0.05) and with III and IV clinical stages (OR: 0.07; p < 0.05). Conclusions in this sample, the frequency of XPD-Gln in IFH suggests that this variant may protect against OSCC. The presence of the XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions.
URI: http://repositorio.ufrn.br/handle/123456789/21200
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