1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DOD - Departamento de Odontologia
4. CCS - DOD - Artigos publicados em periódicos

Title:	Analysis of inflammatory infiltrate, perineural invasion, and risk score can indicate concurrent metastasis in squamous cell carcinoma of the tongue
Authors:	Matos, Felipe Rodrigues de Lima, Emeline das Neves de Araújo Queiroz, Lelia Maria Guedes Silveira, Ericka Janine Dantas da
Keywords:	Neoplasms, Unknown Primary;perineural invasion
Issue Date:	2012
Citation:	MATOS, Felipe Rodrigues de et al. Analysis of inflammatory infiltrate, perineural invasion, and risk score can indicate concurrent metastasis in squamous cell carcinoma of the tongue. Journal of Oral and Maxillofacial Surgery, v. 70, n. 7, p. 1703-1710, 2012.
Portuguese Abstract:	Purpose: In this retrospective study, the aim was to compare individual histopathologic parameters of malignancy between nonmetastatic and metastatic squamous cell carcinoma of the tongue. Materials and Methods: Sixty-two cases of squamous cell carcinoma of the tongue were selected and examined according to the system established by Brandwein-Gensler et al (Am J Surg Pathol 29:167, 2005) and included the pattern of invasion (most to least favorable), lymphocytic infiltration, perineural invasion, risk score, keratinization, eosinophilia, perivascular invasion, and tumor thickness. Results: The least favorable pattern had no association with nodal metastasis (P .05). The scarcity or density of the lymphocytic infiltration, perineural invasion, and a risk score 3 were associated with nodal metastasis (P .05). Keratinization, eosinophilia, perivascular invasion, and tumor thickness had no association with nodal metastasis (P .05). A significant positive correlation was found between the pattern of invasion and perineural invasion and between the pattern of invasion and tumor thickness (P .05). Conclusions: The scarcity or density of the lymphocytic infiltration, perineural invasion, and histopathologic risk score may be helpful as parameters of histologic malignancy for the evaluation of metastatic and nonmetastatic squamous cell carcinoma of the tongue.
URI:	http://hdl.handle.net/123456789/22904
Appears in Collections:	CCS - DOD - Artigos publicados em periódicos

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