Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/jspui/handle/123456789/23178
Título: Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment andMicroglia Activation after Motor Cortex Excitotoxic Injury
Autor(es): Guimarães-Santos, Adriano
Santos, Diego Siqueira
Santos, Ijair Rogério
Lima, Rafael Rodrigues
Pereira, Antonio
Moura, Lucinewton Silva de
Carvalho Jr., Raul Nunes
Lameira, Osmar
Gomes-Leal, Walace
Palavras-chave: Copaiba Oil-Resin;Neuroprotective;Neutrophil Recruitment;Microglia Activation
Data do documento: 16-Nov-2012
Resumo: The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-inflammatory and healing agent. However, there are no investigations on the possible anti-inflammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders.We have investigated the anti-inflammatory and neuroprotective effects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating inflammatory response following an acute damage to the central nervous system.
URI: http://hdl.handle.net/123456789/23178
ISSN: 1741-427X
Aparece nas coleções:ICe - Artigos publicados em periódicos

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