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Title: SurfaceomeDB: a cancer-orientated database for genes encoding cell surface proteins
Authors: Jorge Estefano Santana de Souza
Pedro Alexandre Favoretto Galante
Renan Valieris Bueno de Almeida
Julia Pinheiro Chagas da Cunha
Daniel Takatori Ohara
Lucila Ohno-Machado
Lloyd J. Old
Sandro José de Souza
Keywords: SurfaceomeDB;gene library;cell surface proteins
Issue Date: 2012
Portuguese Abstract: Cell surface proteins (CSPs) are excellent targets for the development of diagnostic and therapeutic reagents, and it is estimated that 10- 20% of all genes in the human genome encode CSPs. In an effort to integrate all data publicly available for genes encoding cell surface proteins, a database (SurfaceomeDB) was developed. SurfaceomeDB is a gene-centered portal containing different types of information, including annotation for gene expression, protein domains, somatic mutations in cancer, and protein-protein interactions for all human genes encoding CSPs. SurfaceomeDB was implemented as an integrative and relational database in a user-friendly web interface, where users can search for gene name, gene annotation, or keywords. There is also a streamlined graphical representation of all data provided and links to the most important data repositories and databases, such as NCBI, UCSC Genome Browser, and EBI.
ISSN: 1424-9634
Appears in Collections:ICe - Artigos publicados em periódicos

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