Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/jspui/handle/123456789/23296
Título: Decreased acetylcholine release delays the consolidation of object recognition memory
Autor(es): Jaeger, Xavier De
Cammarota, Martín
Prado, Marco A.M.
Izquierdo, Iván
Prado, Vania F.
Pereira, Grace S.
Palavras-chave: Acetylcholine;Consolidation;Memory;Object recognition;VAChT
Data do documento: 2013
Resumo: Acetylcholine (ACh) is important for different cognitive functions such as learning, memory and attention. The release of ACh depends on its vesicular loading by the vesicular acetylcholine transporter (VAChT). It has been demonstrated that VAChT expression can modulate object recognition memory. However, the role of VAChT expression on object recognition memory persistence still remains to be understood. To address this question we used distinct mouse lines with reduced expression of VAChT, as well as pharmacological manipulations of the cholinergic system. We showed that reduction of cholinergic tone impairs object recognition memory measured at 24h. Surprisingly, object recognition memory, measured at 4 days after training, was impaired by substantial, but not moderate, reduction in VAChT expression. Our results suggest that levels of acetylcholine release strongly modulate object recognition memory consolidation and appear to be of particular importance for memory persistence 4 days after training.
URI: http://hdl.handle.net/123456789/23296
Aparece nas coleções:ICe - Artigos publicados em periódicos

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