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|Title:||Asymmetry of the temporal code for space by hippocampal place cells|
|Authors:||Souza, Bryan C.|
Tort, Adriano B. L.
|Keywords:||rate coding;temporal coding;hippocampus;theta phase|
|Resumo:||Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that the spike timing of place cells couples to theta phase before major increases in firing rate, anticipating the animal’s entrance into the classical, rate-based place field. In contrast, spikes rapidly decouple from theta as the animal leaves the place field and firing rate decreases. Therefore, temporal coding has strong asymmetry around the place field center. We further show that the dynamics of temporal coding along space evolves in three stages as the animal traverses the place field: phase coupling, sharp precession and phase decoupling. These results suggest that independent mechanisms may govern rate and temporal coding.|
|Appears in Collections:||ICe - Artigos publicados em periódicos|
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|AdrianoTort_ICe_2017_Asymmetry of the temporal.pdf||AdrianoTort_ICe_2017_Asymmetry of the temporal||2,98 MB||Adobe PDF|
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