Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/jspui/handle/123456789/23812
Título: Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma
Autor(es): Soares, Andréa Ferreira
Xavier, Ruth Lopes de Freitas
Miguel, Márcia Cristina da Costa
Souza, Lélia Batista de
Pinto, Leão Pereira
Palavras-chave: Bone morphogenetic protein-4;Squamous cell carcinoma of the head and neck;Epithelial-mesenchymal transition;Invasiveness
Data do documento: 2010
Citação: SOARES, Andréa Ferreira et al. Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma. American Journal of Otolaryngology, v. 31, n. 4, p. 266-271, 2010.
metadata.dc.description.resumo: Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry. Results In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining (P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens. Conclusions The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis.
URI: https://repositorio.ufrn.br/jspui/handle/123456789/23812
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