1. Universidade Federal do Rio Grande do Norte
  2. Centro de Biociências
  3. DBIO - Departamento Biologia
  4. CB - DBIO - Artigos publicados em periódicos
Use este identificador para citar ou linkar para este item: https://repositorio.ufrn.br/handle/123456789/24633
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Campo DCValorIdioma
dc.contributor.authorLuchiari, Ana Carolina-
dc.contributor.authorSalajan, Diana C.-
dc.contributor.authorGerlai, Robert-
dc.date.accessioned2018-01-22T19:27:12Z-
dc.date.available2018-01-22T19:27:12Z-
dc.date.issued2015-
dc.identifier.citationLUCHIARI, Ana Carolina; SALAJAN, Diana C.; ROBERT, Gerlai. Acute and chronic alcohol administration: effects on performance of zebrafish in a latent learning task. Behavioural Brain Research, v. 282, p. 76-83, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0166432814008006?via%3Dihub>. Acesso em: 18 out. 2017.pt_BR
dc.identifier.issn0166-4328-
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/24633-
dc.languageengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLatent learningpt_BR
dc.subjectMemorypt_BR
dc.subjectAlcoholpt_BR
dc.subjectZebrafishpt_BR
dc.subjectHigh-throughput screeningpt_BR
dc.titleAcute and chronic alcohol administration: effects on performance of zebrafish in a latent learning taskpt_BR
dc.typearticlept_BR
dc.identifier.doi10.1016/j.bbr.2014.12.013-
dc.description.resumoAlcohol abuse is a major medical problem. Zebrafish have been proposed to model alcohol related human disorders. Alcohol impairs learning and memory. Here, we analyze the effects of alcohol on performance of zebrafish in a recently developed latent learning paradigm. We employ a 2 × 3 × 2 experimental design (chronic × acute alcohol treatment × path blocked). The latent learning task had two phases: one, 30 min long exploration trials (16 days, 1 trial/day) with left or right path of a complex maze blocked, and two, a subsequent probe trial with all paths open leading to a goal box that now contained stimulus fish. During the 16 days each fish received one of two chronic treatments: freshwater or 0.50% (v/v%) alcohol. Subsequently, fish were immersed for 1 h in one of the following solutions: 0.00 (freshwater), 0.50% or 1.00% alcohol, the acute challenge. Behavior of fish was recorded during the probe trial that commenced immediately after the acute treatment. Path choices, latency to leave the start box and to enter the goal box, time spent in the goal box, distance traveled, and duration of freezing were quantified. We found that acute exposure to 1.00% alcohol after chronic freshwater disrupted learning performance, so did exposure to freshwater after chronic alcohol treatment (withdrawal). We also found exposure to chronic alcohol to diminish the effect of subsequent acute alcohol suggesting development of tolerance. Our results demonstrate that analysis of learning performance of zebrafish allows detection of alcoholinduced functional changes. The simplicity and scalability of the employed task also imply the utility of the zebrafish in high throughput drug screenspt_BR
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