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https://repositorio.ufrn.br/handle/123456789/30195| Título: | Risk-adjusted monitoring of time to event in the presence of long-term survivors |
| Autor(es): | Oliveira, Jocelânio W. Valença, Dione Maria Medeiros, Pledson Guedes Marçula, Magaly |
| Palavras-chave: | Cure rate;Risk-adjusted CUSUM;Statistical process control;Survival analysis |
| Data do documento: | 5-Mai-2016 |
| Editor: | Wiley Online |
| Referência: | OLIVEIRA, J. W.; et al . Risk-adjusted monitoring of time to event in the presence of long-term survivors. Biometrical Journal , v. 1, p. 1-20, 2016. Disponível em:<http://onlinelibrary.wiley.com/doi/10.1002/bimj.201500094/abstract;jsessionid=4A09E7D13DA241C2D1CB00D66E1E7CE9.f03t02>. Acesso em: 06 dez. 2019 DOI: 10.1002/bimj.201500094 |
| Resumo: | The use of control charts for monitoring schemes in medical context should consider adjustments to incorporate the specific risk for each individual. Some authors propose the use of a risk-adjusted survival time cumulative sum (RASTCUSUM) control chart to monitor a time-to-event outcome, possibly right censored, using conventional survival models, which do not contemplate the possibility of cure of a patient. We propose to extend this approach considering a risk-adjusted CUSUM chart, based on a cure rate model. We consider a regression model in which the covariates affect the cure fraction. The CUSUM scores are obtained for Weibull and log-logistic promotion time model to monitor a scale parameter for nonimmune individuals. A simulation study was conducted to evaluate and compare the performance of the proposed chart (RACUF CUSUM) with RAST CUSUM, based on optimal control limits and average run length in different situations.As a result,we note that the RASTCUSUM chart is inappropriate when applied to data with a cure rate, while the proposed RACUF CUSUM chart seems to have similar performance if applied to data without a cure rate. The proposed chart is illustrated with simulated data and with a real data set of patients with heart failure treated at the Heart Institute (InCor), at the University of S˜ao Paulo, Brazil. |
| URI: | https://repositorio.ufrn.br/jspui/handle/123456789/30195 |
| Aparece nas coleções: | CCET - DEST - Artigos publicados em periódicos |
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