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Title: The Bisindole Alkaloid Caulerpin, from seaweeds of the Genus Caulerpa, attenuated colon damage in murine colitis model
Authors: Lucena, Alessandra Marinho Miranda
Souza, Cássio R. M.
Jales, Jéssica T.
Guedes, Paulo Marcos da Matta
Miranda, George E. C. de
Moura, Adolpho M. A. de
Araújo-Júnior, João X.
Nascimento, George J.
Scortecci, Kátia Castanho
Santos, Barbara V. O.
Souto, Janeusa Trindade de
Keywords: Caulerpin;Ulcerative colitis;Anti-inflammatory activity;Cytokines;Tissue damage
Issue Date: 7-Sep-2018
Publisher: MDPI
Citation: LUCENA, Alessandra Marinho Miranda; SOUZA, Cássio R. M.; JALES, Jéssica T.; GUEDES, Paulo Marcos da Matta; MIRANDA, George E. C. de; MOURA, Adolpho M. A. de; ARAÚJO-JÚNIOR, João X.; NASCIMENTO, George J.; SCORTECCI, Kátia Castanho; SANTOS, Barbara V. O.; SOUTO, Janeusa Trindade de. The Bisindole Alkaloid Caulerpin, from seaweeds of the genus Caulerpa, attenuated colon damage in murine colitis model. Marine Drugs, [s. l.], v. 16, n. 9, p. 318, 7 set. 2018. MDPI AG. Disponível em: Acesso em: 19 mar. 2021.
Portuguese Abstract: Caulerpin (CLP), an alkaloid from algae of the genus Caulerpa, has shown anti-inflammatory activity. Therefore, this study aimed to analyze the effect of CLP in the murine model of peritonitis and ulcerative colitis. Firstly, the mice were submitted to peritonitis to evaluate which dose of CLP (40, 4, or 0.4 mg/kg) could decrease the inflammatory infiltration in the peritoneum. The most effective doses were 40 and 4 mg/kg. Then, C57BL/6 mice were submitted to colitis development with 3% dextran sulfate sodium (DSS) and treated with CLP at doses of 40 and 4 mg/kg. The disease development was analyzed through the disease activity index (DAI); furthermore, colonic tissue samples were submitted to histological analysis, NFκB determination, and in vitro culture for cytokines assay. Therefore, CLP at 4 mg/kg presented the best results, triggering improvement of DAI and attenuating the colon shortening and damage. This dose was able to reduce the TNF-α, IFN-γ, IL-6, IL-17, and NFκB p65 levels, and increased the levels of IL-10 in the colon tissue. Thus, CLP mice treatment at a dose of 4 mg/kg showed promising results in ameliorating the damage observed in the ulcerative colitis
ISSN: 1660-3397 (Online)
Appears in Collections:CB - DBG - Artigos publicados em periódicos
CB - DMP - Artigos publicados em periódicos
EMCM - Artigos publicados em periódicos

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