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Title: Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
Authors: Archanjo, Anderson Barros
Assis, Arícia Leone Evangelista Monteiro de
Oliveira, Mayara Mota de
Mendes, Suzanny Oliveira
Borçoi, Aline Ribeiro
Maia, Lucas de Lima
Souza, Rafael Pereira de
Cicco, Rafael de
Saito, Kelly Cristina
Kimura, Edna Teruko
Carvalho, Marcos Brasilino de
Nunes, Fabio Daumas
Tajara, Eloiza H.
Santos, Marcelo dos
Nogueira, Breno Valentim
Trivilin, Leonardo Oliveira
Pinheiro, Christiano Jorge Gomes
Silva, Adriana Madeira Álvares da
Keywords: Tobacco use disorder;Smoke;Carcinoma, Squamous cell;Tumor cells, Cultured
Issue Date: 25-Jun-2020
Publisher: Nature Research
Citation: ARCHANJO, Anderson Barros; ASSIS, Arícia Leone Evangelista Monteiro D.; OLIVEIRA, Mayara Mota de; MENDES, Suzanny Oliveira; BORÇOI, Aline Ribeiro; MAIA, Lucas de Lima; SOUZA, Rafael Pereira de; CICCO, Rafael de; SAITO, Kelly Cristina; KIMURA, Edna Teruko; SANTOS, Marcelo dos. Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival. Scientific Reports, [s. l.], v. 10, n. 1, p. 1-10, 25 jun. 2020. Springer Science and Business Media LLC. Disponível em: Acesso em: 30 mar. 2021.
Portuguese Abstract: Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival
ISSN: 2045-2322 (online)
Appears in Collections:EMCM - Artigos publicados em periódicos

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