Guedes, Paulo Marcos da MattaPereira, Luanderson Cardoso2025-03-212025-03-212024-03-07PEREIRA, Luanderson Cardoso. Avaliação da atividade inseticida do fluralaner (Exzolt®) administrado em galinhas contra triatomíneos. Orientador: Dr. Paulo Marcos da Matta Guedes. 2024. 71f. Dissertação (Mestrado em Biologia Parasitária) - Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, 2024.https://repositorio.ufrn.br/handle/123456789/63161Triatoma infestans, Triatoma brasiliensis, Triatoma pseudomaculata and Rhodnius prolixus are vectors of Trypanosoma cruzi, the etiological agent of Chagas disease, and chickens are important food sources for these insects in anthropogenic environments. The aim of this study was to evaluate the insecticidal activity of fluralaner (Exzolt®) administered to chickens against triatomines (R. prolixus, T. infestans, T. brasiliensis and T. pseudomaculata). Twelve mixed-breed chickens (Gallus gallus domesticus) were randomized, according to weight, into three groups: Group 1 - untreated control (n=4); Group 2 - single dose of 0.5mg/kg of fluralaner (Exzolt®) (n=4); and Group 3 - two doses of 0.5mg/kg of fluralaner (Exzolt®) (n=4). Subsequently, they were subjected to blood feeding using nymphs (n = 10) of 3rd, 4th and 5th instars of T. infestans, T. brasiliensis, T. pseudomaculata and R. prolixus before treatment and 1, 7, 14, 21, 28, 35 and 56 days after treatment. After blood feeding, the feeding efficiency and mortality of triatomine nymphs were determined. The results demonstrate greater feeding success for R. prolixus, followed by T. infestans, T. brasiliensis and T. pseudomaculata, respectively. Treatment of chickens with fluralaner does not affect the blood feeding rate of triatomines. Treatment with two doses of fluralaner showed greater insecticidal activity for R. prolixus, T. infestans and T. brasiliensis, compared to treatment with a single dose. Similar insecticidal efficacy was observed for T. pseudomaculata using single- and double-dose fluralaner treatments. The insecticidal activity of fluralaner (Exzolt®) against triatomines was observed up to 21 and 28 days after single- and double-dose treatment, respectively. Our results demonstrate that treatment of chickens with fluralaner (Exzolt®) induces insecticidal activity against triatomines up to 28 days after treatment and could be used as a control measure for Chagas disease in endemic areas.Acesso AbertoDoença de ChagasFluralanerInseticidamasterThesisCNPQ::CIENCIAS BIOLOGICAS