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Title: Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line
Authors: Araújo, Aurigena Antunes de
Guerra, Andreza Conceição Véras de Aguiar
Soares, Luiz Alberto Lira
Ferreira, Magda Rhayanny Assunção
Rocha, Hugo Alexandre de Oliveira
Medeirose, Juliana Silva de
Cavalcante, Rômulo dos Santos
Araújo Júnior, Raimundo Fernandes de
Keywords: Libidibia ferrea;Colorectal cancer;Apoptosis;Antioxidant
Issue Date: Aug-2017
Publisher: Elsevier
Citation: ARAÚJO, Aurigena Antunes de et al.Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line. Biomedicine & Pharmacotherapy, v. 92, p. 696-706, 2017. Disponível em: <>. Acesso em: 21 mar. 2018.
Portuguese Abstract: Colorectal cancer is noted for being one of the most frequent of tumors, with expressive morbidity and mortality rates. In new drug discovery, plants stand out as a source capable of yielding safe and highefficiency products. Well known in Brazilian popular medicine, Libidibia ferrea (Mart. Ex Tul.) L.P. Queiroz var. ferrea (better known as “ironwood” or “jucá”), has been used to treat a wide spectrum of conditions and to prevent cancer. Using methodologies that involved flow cytometry, spectrophotometry and RT-qPCR assays, crude extracts of the fruits of L. ferrea (20T, 40T, 60T and 80T) were evaluated at 24 h and/or 48 h for: their ability to inhibit cell proliferation; induce apoptosis through Bcl-2, caspase-3 and Apaf-1; their antioxidant activity and effects on important targets related to cell proliferation (EGFR and AKT) in the HT-29 human colorectal cancer lineage. The results revealed high antiproliferative potential as compared to the controls, induction of apoptosis through the intrinsic pathway, and probable tumor inhibition activity under the mediation of important targets in tumorigenesis. In addition, L. ferrea revealed antioxidant, lipid peroxidation and chemoprotective effects in healthy cells. Thus, L. ferrea derivatives have important anticancer effects, and may be considered promising candidate for colorectal cancer therapy.
ISSN: 0753-3322
Appears in Collections:CB - DBF - Artigos publicados em periódicos
CB - DBQ - Artigos publicados em periódicos
CB - DMOR - Artigos publicados em periódicos

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