1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DMI - Departamento de Medicina Integrada
4. CCS - DMI - Artigos publicados em periódicos

Título:	Role of miRNAs in sigmoid colon cancer: a search for potential biomarkers
Autor(es):	Correa, Romualdo da Silva Marques, Diego Costa, Layse Raynara Ferreira Costa, Lorenna Larissa Ferreira Oliveira, Ana Beatriz Bezerra Ramos, Carlos Cesar de Oliveira Sandoval, Tatiana Vinasco Lopes, Katia de Paiva Vialle, Ricardo Assunção Vidal, Amanda Ferreira Silbiger, Vivian Nogueira Santos, Ândrea Ribeiro dos
Palavras-chave:	biomarkers;field-effect;colorectal cancer;miRNome
Data do documento:	10-Nov-2020
Editor:	MDPI
Referência:	CORREA, Romualdo da Silva; MARQUES, Diego; FERREIRA-COSTA, Layse Raynara; FERREIRA-COSTA, Lorenna Larissa; BEZERRA-OLIVEIRA, Ana Beatriz; RAMOS, Carlos Cesar de Oliveira; VINASCO-SANDOVAL, Tatiana; LOPES, Katia de Paiva; VIALLE, Ricardo Assunção; VIDAL, Amanda Ferreira. Role of miRNAs in Sigmoid Colon Cancer: a search for potential biomarkers. Cancers, [S.L.], v. 12, n. 11, p. 3311, 10 nov. 2020. MDPI AG. http://dx.doi.org/10.3390/cancers12113311. Disponível em: https://www.mdpi.com/2072-6694/12/11/3311. Acesso em: 05 jul. 2023.
Resumo:	The aberrant expression of microRNAs in known to play a crucial role in carcinogenesis. Here, we evaluated the miRNA expression profile of sigmoid colon cancer (SCC) compared to adjacent-to-tumor (ADJ) and sigmoid colon healthy (SCH) tissues obtained from colon biopsy extracted from Brazilian patients. Comparisons were performed between each group separately, considering as significant p-values < 0.05 and |Log2(Fold-Change)| > 2. We found 20 differentially expressed miRNAs (DEmiRNAs) in all comparisons, two of which were shared between SCC vs. ADJ and SCC vs. SCH. We used miRTarBase, and miRTargetLink to identify target-genes of the differentially expressed miRNAs, and DAVID and REACTOME databases for gene enrichment analysis. We also used TCGA and GTEx databases to build miRNA-gene regulatory networks and check for the reproducibility in our results. As findings, in addition to previously known miRNAs associated with colorectal cancer, we identified three potential novel biomarkers. We showed that the three types of colon tissue could be clearly distinguished using a panel composed by the 20 DEmiRNAs. Additionally, we found enriched pathways related to the carcinogenic process in which miRNA could be involved, indicating that adjacent-to-tumor tissues may be already altered and cannot be considered as healthy tissues. Overall, we expect that these findings may help in the search for biomarkers to prevent cancer progression or, at least, allow its early detection, however, more studies are needed to confirm our results.
URI:	https://repositorio.ufrn.br/handle/123456789/53101
Aparece nas coleções:	CCS - DMI - Artigos publicados em periódicos

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