Effect of carotenoid encapsulation on antioxidant activities: a protocol for systematic review

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dc.contributor.authorMorais, Ana Heloneida de Araujo
dc.contributor.authorQueiroz, Jaluza Luana Carvalho de
dc.contributor.authorMedeiros, Isaiane
dc.contributor.authorPiuvezam, Grasiela
dc.contributor.authorNunes, Ana Clara de França
dc.contributor.authorGomes, Camila Carvalho
dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorPassos, Thaís Souza
dc.contributor.authorIDhttps://orcid.org/0000-0002-6460-911Xpt_BR
dc.date.accessioned2023-08-15T22:38:44Z
dc.date.available2023-08-15T22:38:44Z
dc.date.issued2020
dc.description.resumoBackground: Carotenoids play essential roles in human health, such as antioxidant activity, and therefore can decrease free radicals oxidation action, preventing numerous diseases. However, these compounds have an unstable nature, turning them susceptible to adverse conditions in food processing and storage. Thereby the search for alternatives that maintain and enhance carotenoid antioxidant function, such as encapsulation, has grown. The objective of this study was to establish a systematic review protocol to evaluate the effect of different encapsulation techniques on the antioxidant action of carotenoids, evaluating which one is the best and safest, and their role in enhancing the antioxidant activity. Methods: This protocol was guided by the preferred reporting items for protocols for systematic reviews and meta-analyzes. The databases to be searched are PubMed, EMBASE, Scopus, ScienceDirect, and Web of Science. Experimental studies conducted in rats and mice (in vivo) of both sexes and ages, evaluating the use of encapsulated and crude carotenoids will be included in the systematic review. The characteristics of the studies, the experimental model, and the main results will be described, and the risk of bias assessment will be evaluated. Three independent reviewers will proceed with the selection of studies, data extraction, and methodological quality assessment. A narrative synthesis will be made for the included studies. Besides, if sufficient qualitative data is available, a meta-analysis will be conducted. I2 statistics will be used to assess heterogeneity. Results: This protocol will guide the production of a systematic review that can determine the effect of different encapsulation techniques and encapsulating agents on the antioxidant action of carotenoids. Thus, it will enable the determination of the best encapsulation techniques to promote the preservation and increase of the antioxidant activity, contributing to future research that may reproduce the best carotenoid encapsulation technique in an animal model. Conclusion: The systematic review to be produced from this protocol will provide support for the construction of research that evaluates the effect of encapsulation on the antioxidant function of carotenoids and its possible application as a nutraceutical, considering that this functionality is directly associated with health promotion. Record of systematic review: This review was recorded in the International Register of Prospective Systematic Reviews on January 22, 2020 (registration: CRD42020142065). Available at: https://www.crd.york.ac.uk/prospe /display_record.php?ID=CRD42020142065 Abbreviations: CAPES = coordination of improvement of higher education personnel, CNPQ = National Council for Scientific and Technological Development, MeSH = Medical Subject Headingspt_BR
dc.identifier.citationQUEIROZ, Jaluza Luana Carvalho de. et al. Effect of carotenoid encapsulation on antioxidant activities: a protocol for systematic review. Medicine, v. 99, n. 16, 2020.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1097/MD.0000000000019772
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54489
dc.languageenpt_BR
dc.publisherMedicinept_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectAntioxidantpt_BR
dc.subjectcarotenoidspt_BR
dc.subjectoxidative stresspt_BR
dc.subjectoxygen radical absorbance capacitypt_BR
dc.subjectreactive oxygen speciespt_BR
dc.subjectsystematic reviewpt_BR
dc.titleEffect of carotenoid encapsulation on antioxidant activities: a protocol for systematic reviewpt_BR
dc.typearticlept_BR

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