Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use

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dc.contributor.advisorSilva Júnior, Arnóbio Antônio da
dc.contributor.advisor-co1Lucas Azevedo do Nascimentopt_BR
dc.contributor.authorSantos, Milena Lima Valério dos
dc.contributor.referees1Medeiros, Arthur Sérgio Avelino de
dc.contributor.referees2Silva, Edilamar Pereira da
dc.date.accessioned2019-11-22T19:46:11Z
dc.date.accessioned2021-09-20T17:51:12Z
dc.date.available2019-11-22T19:46:11Z
dc.date.issued2019-11-06
dc.description.embargo2022-01-01
dc.description.resumoIbuprofen (IBF) is a non-steroidal anti-inflammatory drug (NSAID) that has analgesic, antipyretic and anti-inflammatory action, but is a poorly soluble drug. Aiming at improving the bioavailability of this drug, this study aimed to develop ibuprofen-containing nanoemulsions (NE) and gelatinized nanoemulsions (NEG) for possible topical use. Nanoemulsions were prepared using low energy technique at different surfactant concentrations. For the gelation of nanoemulsions a copolymer with thermoreversible properties was used in different proportions, being Poloxamer 407 (Pluronic F127®). The characteristics of both systems were evaluated with respect to average droplet size, polydispersion index and zeta potential. All samples presented nanometer droplet size and negative zeta potential; The polydispersion index values were variable. The selected nanoemulsion was translucent and had stable droplet size and polydispersion index over a period of 60 days. This system then received ibuprofen and the same characteristics were evaluated and the formulation was stable for 15 days. Afterwards, the empty and drug nanoemulsions were gelled with Pluronic F127® (F127) and maintained their stability for more than 40 days, maintaining their nanometric characteristics during the study. In addition, the in vitro release study showed that within 6 hours, it is possible that about 50% of the drug will be released, and after that release will remain constant. Thus, we can see that the development of NE can improve the bioavailability of IBF and that nanogels are a vehicle option for improving topical administration of this drug.pt_BR
dc.identifier20150118353pt_BR
dc.identifier.citationSANTOS, Milena Lima Valério dos. Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use. 2019. 26f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/35774
dc.languageenpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFarmáciapt_BR
dc.publisher.initialsUFRNpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectNanoemulsionpt_BR
dc.subjectNanogelpt_BR
dc.subjectIbuprofenpt_BR
dc.subjectPoloxamer 407pt_BR
dc.titleDevelopment of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical usept_BR
dc.typebachelorThesispt_BR

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