Beneficial effects of tamarind trypsin inhibitor in chitosan–whey protein nanoparticles on hepatic injury induced high glycemic index diet: a preclinical study

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dc.contributor.authorMorais, Ana Heloneida de Araujo
dc.contributor.authorAguiar, Ana J. F. C.
dc.contributor.authorQueiroz, Jaluza L. C. de
dc.contributor.authorSantos, Pedro P. A.
dc.contributor.authorCamillo, Christina S.
dc.contributor.authorSerquiz, Alexandre C.
dc.contributor.authorCosta, Izael S.
dc.contributor.authorOliveira, Gerciane S.
dc.contributor.authorGomes, Ana F. T.
dc.contributor.authorMatias, Lídia L. R.
dc.contributor.authorCosta, Rafael O. A.
dc.contributor.authorPassos, Thaís S.
dc.contributor.authorIDhttps://orcid.org/0000-0002-6460-911Xpt_BR
dc.date.accessioned2023-08-15T21:08:28Z
dc.date.available2023-08-15T21:08:28Z
dc.date.issued2021
dc.description.resumoSeveral studies have sought new therapies for obesity and liver diseases. This study investigated the effect of the trypsin inhibitor isolated from tamarind seeds (TTI), nanoencapsulated in chitosan and whey protein isolate (ECW), on the liver health status of the Wistar rats fed with a high glycemic index (HGLI) diet. The nanoformulations without TTI (CW) and ECW were obtained by nanoprecipitation technique, physically and chemically characterized, and then administered to the animals. The adult male Wistar rats (n = 20) were allocated to four groups: HGLI diet + water; standard diet + water; HGLI diet + ECW (12.5 mg/kg); and HGLI diet + CW (10.0 mg/kg), 1 mL per gagave, for ten days. They were evaluated using biochemical and hematological parameters, Fibrosis 4 Index for Liver Fibrosis (FIB-4), AST to Platelet Ratio Index (APRI) scores, and liver morphology. Both nanoparticles presented spherical shape, smooth surface, and nanometric size [120.7 nm (ECW) and 136.4 nm (CW)]. In animals, ECW reduced (p < 0.05) blood glucose (17%), glutamic oxalacetic transaminase (39%), and alkaline phosphatase (24%). Besides, ECW reduced (p < 0.05) APRI and FIB-4 scores and presented a better aspect of hepatic morphology. ECW promoted benefits over a liver injury caused by the HGLI dietpt_BR
dc.identifier.citationAGUIAR, Ana J. F. C. et al. Beneficial effects of tamarind trypsin inhibitor in chitosan–whey protein nanoparticles on hepatic injury induced high glycemic index diet: a preclinical study. International Journal of Molecular Sciences, v. 22, n. 18, p. 9968, 2021.pt_BR
dc.identifier.doihttps://doi.org/10.3390/ijms22189968
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54482
dc.languageenpt_BR
dc.publisherInternational Journal Molecular Sciencespt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectNanoencapsulationpt_BR
dc.subjectprotease inhibitorpt_BR
dc.subjecthyperglycemiapt_BR
dc.titleBeneficial effects of tamarind trypsin inhibitor in chitosan–whey protein nanoparticles on hepatic injury induced high glycemic index diet: a preclinical studypt_BR
dc.typearticlept_BR

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