Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient
| dc.contributor.author | Vechi, Hareton Teixeira | |
| dc.contributor.author | Sousa, Ana Solange Vasconcelos de | |
| dc.contributor.author | Cunha, Mirella Alves da | |
| dc.contributor.author | Shaw, Jeffrey Jon | |
| dc.contributor.author | Luz, Kleber Giovanni | |
| dc.date.accessioned | 2022-01-17T16:25:08Z | |
| dc.date.available | 2022-01-17T16:25:08Z | |
| dc.date.issued | 2020-02-05 | |
| dc.description.resumo | In immunocompromised patients, visceral leishmaniasis (VL) can present with atypical clinical symptoms that include poorresponse to treatment.Nooptimal therapeuticregimen is available for such cases. In a splenectomizedmale patient, we observed a disseminated form of the disease in the liver, bone marrow, lymph nodes, and gastrointestinal tract. Therewas an apparent clinical improvementwhenhewas initiallytreatedwith liposomal amphotericin B (L-AmB), butthiswas followed by a relapse involving severe clinical symptoms. He was finally treated successfully with a combination of L-AmB, meglumine antimoniate, and pentamidine isethionate. It is important to include asplenia as an immunosuppressive condition that induces exotic VL pathologies. In such cases, combination anti-Leishmania drug therapy should be considered | pt_BR |
| dc.identifier.citation | VECHI, Hareton Teixeira et al. Case Report: combination therapy with liposomal amphotericin b, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient. The American Journal Of Tropical Medicine And Hygiene, [s. l.], v. 102, n. 2, p. 268-273, 5 fev. 2020. American Society of Tropical Medicine and Hygiene. http://dx.doi.org/10.4269/ajtmh.18-0999. Disponível em: http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0999. Acesso em: 16 out. 2020. | pt_BR |
| dc.identifier.doi | 10.4269/ajtmh.18-0999 | |
| dc.identifier.issn | 0002-9637 (print) | |
| dc.identifier.uri | https://repositorio.ufrn.br/handle/123456789/45639 | |
| dc.language | en | pt_BR |
| dc.publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| dc.subject | Visceral leishmaniasis | pt_BR |
| dc.subject | Splenectomized Adult Patient | pt_BR |
| dc.title | Case report: combination therapy with liposomal amphotericin B, n-methyl meglumine antimoniate, and pentamidine isethionate for disseminated visceral leishmaniasis in a splenectomized adult patient | pt_BR |
| dc.type | article | pt_BR |
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