Tuberculose multirresistente no Brasil

Abstract

Tuberculosis (TB) is a chronic infectious disease, mainly caused by Mycobacterium tuberculosis, also known as Koch's bacillus (BK). Although TB is a curable disease, it remains one of the top ten causes of death in the world. One of the main obstacles to the control of the disease is the lack of adherence to treatment, the inadequate and irregular use of medicines for an insufficient time, this makes BK resistant to antiTB. Resistance to these drugs has become a reality on the world stage, specifically when related to rifampicin and isoniazid, characterizing resistant multidrug TB (MDR-TB). As an objective, the work aims to carry out a literature review about tuberculosis and the implications of its state of multidrug resistance in brazil. The methodology it consisted of a reviewing the literature of articles, data from the Brazilian government, scientific journals, dissertations and academic theses using SciELO, Google Scholar, PubMed and MEDLINE in the period from 2013 to 2020. Twenty-seven documents were analyzed and, according to them, it was possible to determine which strategies such as knowledge of the biology of the etiologic agent, early diagnosis, knowledge of bacillus resistance mechanisms, drug sensitivity tests, appropriate treatment of the disease and epidemiological record of TB. All of these mechanisms are major determinants for the cure and reduction of mortality caused by the disease to be achieved more quickly, as well as the reduction of cases of MDR-TB.