Linseed oil microemulsion for ivermectin delivery: production and biosafety assessment

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dc.contributor.advisorEgito, Eryvaldo Sócrates Tabosa do
dc.contributor.advisor-co1Oliveira, Wógenes Nunes
dc.contributor.authorGirão, Ícaro Chaves
dc.contributor.authorCruz, Yasmin Ferreira
dc.contributor.authorMiranda, Júlio Abreu
dc.contributor.authorOliveira, Wógenes Nunes
dc.contributor.authorEgito, Eryvaldo Sócrates Tabosa do
dc.contributor.referees1Veríssimo, Lourena Mafra
dc.contributor.referees2Machado, Lucas Amaral
dc.date.accessioned2024-07-29T21:29:52Z
dc.date.available2024-07-29T21:29:52Z
dc.date.issued2024-06-19
dc.description.resumoIvermetcin (IVM) is an antiparasitic drug used worldwide due to its broad spectrum of action and low cost. However, the current drug dosage forms for IVM present drawbacks that compromises the treatment, as difficulties in administration in animals and limited skin permeation. Then, the aim of this work is to produce a microemulsion to deliver IVM for the treatment of parasitic infections in dogs. The IVM microemulsion (IVM-MeLO) composed by purified water (70 %), linseed oil (5 %), Kolliphor® RH40 (21.75 %), Span® 80 (3.25 %) and IVM (1.95 %) was produced and characterized by hydrodynamic diameter, polydispersity index (PdI), pH, conductivity, entrapment efficiency in addition to the physicochemical and chemical stability, and hemolytic potential. Results indicated that the IVM-MeLO exhibited hydrodynamic diameter of 21.7 ± 0.2 nm, PdI of 0.10 ± 0.01, pH value of 5.3 ± 0.05, electrical conductivity of 318 ± 2.00 μS.cm-1 and entrapment efficiency 93.92 ± 3.76%, data related to the microemulsified systems features. The IVM also did not showed any instability phenomena in the stability study conducted. In addition, no hemolytic effect was observed, suggesting a promising biocompatibility. These findings highlight the potential of the IVM-MeLO as a non-toxic and stable formulation, which can be used in further studies as an alternative for cutaneous parasitic infections.pt_BR
dc.description.sponsorshipCAPESpt_BR
dc.description.sponsorshipCNPqpt_BR
dc.identifier.citationGIRÃO, Ícaro Chaves et al. Linseed oil microemulsion for ivermectin delivery: production and biosafety assessment. Orientador: Eryvaldo Sócrates Egito. 2024. 38 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2024.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/58899
dc.languageenpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentDepartamento de Farmáciapt_BR
dc.publisher.initialsUFRNpt_BR
dc.publisher.programFarmáciapt_BR
dc.subjectMicroemulsionpt_BR
dc.subjectIvermectinpt_BR
dc.subjectLinseed oilpt_BR
dc.subjectVeterinarypt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.titleLinseed oil microemulsion for ivermectin delivery: production and biosafety assessmentpt_BR
dc.typebachelorThesispt_BR

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