Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer

Rodrigues, P. R. S.; Maia, L. L.; Santos, Marcelo dos; Peterle, G. T.; Alves, L. U.; Takamori, J. T.; Souza, R. P.; Barbosa, W. M.; Mercante, A. M. C.; Nunes, F. D.; Carvalho, M. B.; Tajara, E. H.; Louro, I. D.; Silva-Conforti, A. M. A.

Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer

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dc.contributor.author	Rodrigues, P. R. S.
dc.contributor.author	Maia, L. L.
dc.contributor.author	Santos, Marcelo dos
dc.contributor.author	Peterle, G. T.
dc.contributor.author	Alves, L. U.
dc.contributor.author	Takamori, J. T.
dc.contributor.author	Souza, R. P.
dc.contributor.author	Barbosa, W. M.
dc.contributor.author	Mercante, A. M. C.
dc.contributor.author	Nunes, F. D.
dc.contributor.author	Carvalho, M. B.
dc.contributor.author	Tajara, E. H.
dc.contributor.author	Louro, I. D.
dc.contributor.author	Silva-Conforti, A. M. A.
dc.date.accessioned	2021-02-09T17:33:14Z
dc.date.available	2021-02-09T17:33:14Z
dc.date.issued	2015-11-24
dc.description.resumo	The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types. Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood. In this study, 315 DNA samples were used for LEPR Gln223Arg genotyping and 87 primary oral and oropharyngeal squamous cell carcinomas were used for immunohistochemical expression analysis, such that a relationship between these and tumor development and prognosis could be established. Homozygous LEPR Arg223 was found to be associated with a 2-fold reduction in oral and oropharyngeal cancer risk. In contrast, the presence of the Arg223 allele in tumors was associated with worse disease-free and disease-specific survival. Low LEPR expression was found to be an independent risk factor, increasing the risk for lymph node metastasis 4-fold. In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapies	pt_BR
dc.identifier.citation	RODRIGUES, P. R. S. et al. Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer. Genetics and Molecular Research, [s. l.], v. 14, n. 4, p. 14979-14988, 2015. Disponível em: http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr6275.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.november.24.5	pt_BR
dc.identifier.doi	10.4238/2015.november.24.5
dc.identifier.issn	1676-5680 (print)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31434
dc.language	en	pt_BR
dc.publisher	Fundação de Pesquisas de Ribeirão Preto	pt_BR
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/br/	*
dc.subject	LEPR expression	pt_BR
dc.subject	Gln223Arg	pt_BR
dc.subject	Prognostic marker	pt_BR
dc.subject	Head and neck cancer	pt_BR
dc.title	Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer	pt_BR
dc.type	article	pt_BR