Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke

Leoni, Renata F.; Paiva, Fernando F.; Kang, Byeong-Teck; Henning, Erica C.; Nascimento, George Carlos; Tannús, Alberto; Araújo, Dráulio Barros de; Silva, Afonso C.

Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke

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dc.contributor.author	Leoni, Renata F.
dc.contributor.author	Paiva, Fernando F.
dc.contributor.author	Kang, Byeong-Teck
dc.contributor.author	Henning, Erica C.
dc.contributor.author	Nascimento, George Carlos
dc.contributor.author	Tannús, Alberto
dc.contributor.author	Araújo, Dráulio Barros de
dc.contributor.author	Silva, Afonso C.
dc.date.accessioned	2017-05-29T12:42:04Z
dc.date.available	2017-05-29T12:42:04Z
dc.date.issued	2011
dc.description.resumo	Collateral circulation, defined as the supplementary vascular network that maintains cerebral blood flow (CBF) when the main vessels fail, constitutes one important defense mechanism of the brain against ischemic stroke. In the present study, continuous arterial spin labeling (CASL) was used to quantify CBF and obtain perfusion territory maps of the major cerebral arteries in spontaneously hypertensive rats (SHRs) and their normotensive Wistar-Kyoto (WKY) controls. Results show that both WKY and SHR have complementary, yet significantly asymmetric perfusion territories. Right or left dominances were observed in territories of the anterior (ACA), middle and posterior cerebral arteries, and the thalamic artery. Magnetic resonance angiography showed that some of the asymmetries were correlated with variations of the ACA. The leptomeningeal circulation perfusing the outer layers of the cortex was observed as well. Significant and permanent changes in perfusion territories were obtained after temporary occlusion of the right middle cerebral artery in both SHR and WKY, regardless of their particular dominance. However, animals with right dominance presented a larger volume change of the left perfusion territory (23±9%) than animals with left dominance (7±5%, P<0.002). The data suggest that animals with contralesional dominance primarily safeguard local CBF values with small changes in contralesional perfusion territory, while animals with ipsilesional dominance show a reversal of dominance and a substantial increase in contralesional perfusion territory. These findings show the usefulness of CASL to probe the collateral circulation.	pt_BR
dc.identifier.issn	1868-4483
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23166
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Cerebral blood flow	pt_BR
dc.subject	Collateral flow	pt_BR
dc.subject	Magnetic resonance imaging	pt_BR
dc.subject	Vascular territory	pt_BR
dc.title	Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke	pt_BR
dc.type	article	pt_BR