JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

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dc.contributor.authorMaia, Lucas de Lima
dc.contributor.authorPeterle, Gabriela Tonini
dc.contributor.authorSantos, Marcelo dos
dc.contributor.authorTrivilin, Leonardo Oliveira
dc.contributor.authorMendes, Suzanny Oliveira
dc.contributor.authorOliveira, Mayara Mota de
dc.contributor.authorSantos, Joaquim Gasparini dos
dc.contributor.authorStur, Elaine
dc.contributor.authorAgostini, Lidiane Pignaton
dc.contributor.authorCouto, Cinthia Vidal Monteiro da Silva
dc.contributor.authorDalbo, Juliana
dc.contributor.authorAssis, Arícia Leone Evangelista Monteiro de
dc.contributor.authorArchanjo, Anderson Barros
dc.contributor.authorMercante, Ana Maria Da Cunha
dc.contributor.authorLopez, Rossana Veronica Mendoza
dc.contributor.authorNunes, Fábio Daumas
dc.contributor.authorCarvalho, Marcos Brasilino de
dc.contributor.authorTajara, Eloiza Helena
dc.contributor.authorLouro, Iúri Drumond
dc.contributor.authorÁlvares-da-Silva, Adriana Madeira
dc.date.accessioned2021-02-02T10:48:19Z
dc.date.available2021-02-02T10:48:19Z
dc.date.issued2018-03-28
dc.description.resumoAims: Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results: We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffinembedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion: JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targetspt_BR
dc.identifier.citationMAIA, Lucas de Lima; PETERLE, Gabriela Tonini; SANTOS, Marcelo dos; TRIVILIN, Leonardo Oliveira; MENDES, Suzanny Oliveira; OLIVEIRA, Mayara Mota de; SANTOS, Joaquim Gasparini dos; STUR, Elaine; AGOSTINI, Lidiane Pignaton; COUTO, Cinthia Vidal Monteiro da Silva; DALBO, Juliana; ASSIS, Aricia Leone Evangelista Monteiro de; ARCHANJO, Anderson Barros; MERCANTE, Ana Maria da Cunha; LOPEZ, Rossana Veronica Mendonza; NUNES, Fábio Daumas; CARVALHO, Marcos Brasilino de; TAJARA, Eloiza Helena; LOURO, Iúri Drumond Louro; ÁLVARES-DA-SILVA, Adriana Madeira. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. Plos One, [s. l.], v. 13, n. 3, p. 1-16, mar. 2018. Public Library of Science (PLoS). Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194884. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1371/journal.pone.0194884.pt_BR
dc.identifier.doi10.1371/journal.pone.0194884
dc.identifier.issn1932-6203 (online)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/31330
dc.languageenpt_BR
dc.publisherPublic Library of Sciencept_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectCarcinoma, Squamous Cellpt_BR
dc.subjectEpigenesis, Geneticpt_BR
dc.subjectLymphatic Metastasispt_BR
dc.subjectMouth Neoplasmspt_BR
dc.subjectNeoplasm Recurrence, Localpt_BR
dc.subjectOropharyngeal Neoplasmspt_BR
dc.titleJMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinomapt_BR
dc.typearticlept_BR

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