Challenges of the intensive insulin therapy in experimental models of extensive burn injury

Quintana, Hananiah Tardivo; Baptista, Vivianne Izabelle de Araújo; Lazzarin, Mariana Cruz; Oliveira, Flavia de

Challenges of the intensive insulin therapy in experimental models of extensive burn injury

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dc.contributor.author	Quintana, Hananiah Tardivo
dc.contributor.author	Baptista, Vivianne Izabelle de Araújo
dc.contributor.author	Lazzarin, Mariana Cruz
dc.contributor.author	Oliveira, Flavia de
dc.date.accessioned	2020-12-17T14:11:58Z
dc.date.available	2020-12-17T14:11:58Z
dc.date.issued	2020-08-30
dc.description.resumo	Burn injuries (BI) above 40% of total body surface area (TBSA) are considered extensive and associated to systemic responses. The intensive insulin therapy (IIT) has been chosen as treatment because of its anabolic and anti-inflammatory properties, and by glycemic control. Several experimental models of extensive BI with IIT has just been studied, however they have many variables and challenges. Thus, this review aims to investigate the animal models of extensive BI with IIT, in order to better understanding benefits and limitations of this therapy. The review of papers published on the literature and indexed on the PubMed database was conducted by searching the keywords predetermined. Insulin administration after BI is able to revert hyperglycemia state, accelerate wound healing, decrease the mRNA expression of some pro-inflammatory cytokines, attenuate acute lung injuries, decrease inflammation in intestinal epithelium and attenuate the muscle loss. We can conclude, although there are limitations related to burn standard or insulin administration, the systemic benefits of ITT overcome limitations	pt_BR
dc.identifier.citation	QUINTANA, Hananiah Tardivo; BAPTISTA, Vivianne Izabelle de Araújo; LAZZARIN, Mariana Cruz; OLIVEIRA, Flavia de. Challenges of the intensive insulin therapy in experimental models of extensive burn injury. World Journal Of Advanced Research And Reviews, [s. l.], v. 7, n. 2, p. 34-44, 30 ago. 2020. Disponível em: https://wjarr.com/content/challenges-intensive-insulin-therapy-experimental-models-extensive-burn-injury. Acesso em: 03 nov. 2020. http://dx.doi.org/10.30574/wjarr.2020.7.2.0277	pt_BR
dc.identifier.doi	10.30574/wjarr.2020.7.2.0277
dc.identifier.issn	2581-9615
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31036
dc.language	en	pt_BR
dc.publisher	World Journal Series	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Burn	pt_BR
dc.subject	Insulin	pt_BR
dc.subject	Metabolism	pt_BR
dc.subject	Intensive insulin therapy	pt_BR
dc.subject	Insulin resistance	pt_BR
dc.title	Challenges of the intensive insulin therapy in experimental models of extensive burn injury	pt_BR
dc.type	article	pt_BR