Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review

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dc.contributor.authorMorais, Ana Heloneida de Araujo
dc.contributor.authorNascimento, Amanda Maria de Souza
dc.contributor.authorOliveira Segundo, Victor Hugo de
dc.contributor.authorAguiar, Ana Julia Felipe Camelo
dc.contributor.authorPiuvezam, Grasiela
dc.contributor.authorPassos, Tha ıs Souza
dc.contributor.authorDamasceno, Karla Suzanne Florentino da Silva Chaves
dc.contributor.authorIDhttp://lattes.cnpq.br/1233944493334651pt_BR
dc.date.accessioned2023-07-11T20:49:33Z
dc.date.available2023-07-11T20:49:33Z
dc.date.issued2022
dc.description.resumoThis systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibac terial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demon strated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous pro teases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health.pt_BR
dc.identifier.citationNASCIMENTO, Amanda Maria de Souza et al. Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37, n. 1, p. 749-759, 2022. Disponível em: https://www.tandfonline.com/doi/full/10.1080/14756366.2022.2039918. Acesso em: 11 jul. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1080/14756366.2022.2039918
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/53243
dc.languageenpt_BR
dc.publisherTaylor & Francispt_BR
dc.subjectAntimicrobial peptidespt_BR
dc.subjectbioactive proteinspt_BR
dc.subjectinfectious diseasespt_BR
dc.subjectbacteriapt_BR
dc.titleAntibacterial action mechanisms and mode of trypsin inhibitors: a systematic reviewpt_BR
dc.typearticlept_BR

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