Phenolic profile and antioxidant activity from peels and seeds of melon (Cucumis melo L. var. reticulatus) and their antiproliferative effect in cancer cells

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dc.contributor.authorSantos, Everaldo Silvino dos
dc.contributor.authorRolim, Priscilla Moura
dc.contributor.authorFidelis, Gabriel Pereira
dc.contributor.authorPadilha, Carlos Eduardo de Araújo
dc.contributor.authorRocha, Hugo Alexandre de Oliveira
dc.contributor.authorMacedo, Gorete Ribeiro de
dc.date.accessioned2021-05-28T13:05:16Z
dc.date.available2021-05-28T13:05:16Z
dc.date.issued2018
dc.description.resumoMelon (Cucumis melo L.) has high economic value and in recent years, its production has increased; however, part of the fruit is wasted. Usually, inedible parts such as peel and seeds are discarded during processing and consumption. Extracts of melon residues were prepared and their phenolic compounds, antioxidants and antiproliferative activities were evaluated. Total phenolic compounds were found in hydroethanolic, hydromethanolic, and aqueous extracts, especially for melon peel (1.016 mg gallic acid equivalent/100 g). Flavonoids total content found for melon peel aqueous extract was 262 mg of catechin equivalent (CA)/ 100 g. In all extracts of melon peel significant amounts of gallic acid, catechin, and eugenol were found. For total antioxidant capacity, reported as ascorbic acid equivalent, the hydroethanolic and hydromethanolic extracts in peels and hydromethanolic in seeds were 89, 74, and 83 mg/g, respectively. Different extracts of melon showed iron and copper ions chelating activity at different concentrations, especially melon peel aqueous extract, reaching values of 61% for iron and 84% for copper. The hydroethanolic extract of melon peel presented a significant ability for hydroxyl radicals scavenging (68%). To assess the antiproliferative potential in human cancer cell lines, such as kidney carcinoma, colorectal carcinoma, cervical adenocarcinoma and cervical carcinoma, MTT assay was performed. The proliferation was inhibited by 20–85% at extracts concentrations of 0.1–1.0 mg/mL in all cancer cell lines. The results suggest that melon residues extracts display a high antioxidant activity in in vitro assays and have effective biological activity against the growth of human tumor cells.pt_BR
dc.identifier.citationROLIM, P. M. ; FIDELIS, G. ; PADILHA, C. E. ; SANTOS, E. S. ; Rocha, H. A. O. ; Macedo, Gorete R. . Phenolic profile and antioxidant activity from peels and seeds of melon (Cucumis melo L. var. reticulatus) and their antiproliferative effect in cancer cells. Brazilian Journal of Medical and Biological Research (on line), v. 51, p. 1-14, 2018. Disponível em https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400607&tlng=en. Acesso em: 13 abr. 2021. https://doi.org/10.1590/1414-431X20176069.pt_BR
dc.identifier.doi10.1590/1414-431x20176069
dc.identifier.issn0100-879X
dc.identifier.issn1414-431X
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/32584
dc.languageenpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectMelon residuespt_BR
dc.subjectAntioxidant activitypt_BR
dc.subjectCancer cellspt_BR
dc.subjectFree radical scavenging activitypt_BR
dc.subjectMetal chelatorpt_BR
dc.subjectCytotoxicitypt_BR
dc.titlePhenolic profile and antioxidant activity from peels and seeds of melon (Cucumis melo L. var. reticulatus) and their antiproliferative effect in cancer cellspt_BR
dc.typearticlept_BR

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