Formulação de nanoemulsão contendo o óleo de andiroba

Abstract

Antimicrobials were and continue to be very important for humanity, since they managed to reduce deaths caused by diseases caused by microorganisms. However, the use of these drugs was inadequate, which generated resistance on the part of these living beings and made the use of some drugs unfeasible at present, hence the importance of developing new drug therapies against these organisms. The andiroba is a tree that is very present in the Amazon region and was already used by the indigenous people of that town for various therapeutic purposes. Some studies sought to investigate part of these medicinal properties. However, these studies had not worked with the fixed oil of the plant, and few addressed the antimicrobial effect. Because of this, the use of nanotechnology was considered to develop a nanoemulsion with andiroba oil. Therefore, the objective of this work was to develop and characterize a nanoemulsion formulation containing fixed andiroba oil filtered by a low shear technique, through phase inversion. The prepared formulation was characterized by analyzing the particle diameter, the Polydispersion Index, the Zeta Potential and the Hydrogen Ionic Potential. In fact, it was possible to develop a stable nanoemulsion, in addition to characterizing the concentration of oil and the proportion of surfactants suitable for its use.