Síntese, elucidação estrutural e prospecção de atividade antitumoral de hidrazonas

Abstract

Hydrazones are compounds of great interest to the technical-scientific community, since their nucleus has several applications from the technological area to the pharmaceutical sciences, among all this potentials, the ability to act as an antineoplastic agent stands out. The objective of the work was the preparation of nine compounds starting from a drug used as treatment of tuberculosis, isoniazid, reacting with aromatic aldehydes conveniently substituted, in ethanol 98% (v / v) with yields from 25% to 92%. The molecules were isolated from the reaction and subsequently purified when necessary. The compounds were subjected to analysis by thin-layer chromatography, melting point determination, infrared spectroscopy and 13C nuclear magnetic resonance, confirming the formation of the desired hydrazones. All prepared compounds were sent for in vitro antitumor evaluation against the breast cancer cell line.