Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit
| Author | Hilscher, Markus M.; Leão, Emelie Katarina Svahn; Leão, Richardson Naves | |
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| Date | 2013-07-23 | |
| Keywords | hippocampus synchronization dynamic clamp Ih AMPA NMDA | |
| Abstract | Synchronizationamongneuronsisthoughttoarisefromtheinterplaybetweenexcitationandinhibition;however,theconnectivityrulesthatcontributetosynchronizationarestillunknown.WestudiedtheseissuesinhippocampalCA1microcircuitsusingpairedpatchclamprecordingsandrealtimecomputing.Byvirtuallyconnectingamodelinterneuronwithtwopyramidalcells(PCs),wewereabletotesttheimportanceofconnectivityinsynchronizingpyramidalcellactivity.OurresultsshowthatacircuitwithanonreciprocalconnectionbetweenpyramidalcellsandnofeedbackfromPCstothevirtualinterneuronproducedthegreatestlevelofsynchronizationandmutualinformationbetweenPCspikingactivity.Moreover,weinvestigatedtheroleofintrinsicmembranepropertiescontributingtosynchronizationwheretheapplicationofaspecificionchannelblocker,ZD7288dramaticallyimpairedPCsynchronization.Additionally,backgroundsynapticactivity,inparticulararisingfromNMDAreceptors,hasalargeimpactonthesynchronyobservedintheaforementionedcircuit.Ourresultsgivenewinsightstothebasicconnectionparadigmsofmicrocircuitsthatleadtocoordinationandtheformationofassemblies. | |
| URI | https://repositorio.ufrn.br/jspui/handle/123456789/23330 | |
| Collections | ICe - Artigos publicados em periódicos |
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