Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit
dc.contributor.author | Hilscher, Markus M. | |
dc.contributor.author | Leão, Emelie Katarina Svahn | |
dc.contributor.author | Leão, Richardson Naves | |
dc.date.accessioned | 2017-06-01T12:39:36Z | |
dc.date.available | 2017-06-01T12:39:36Z | |
dc.date.issued | 2013-07-23 | |
dc.description.resumo | Synchronizationamongneuronsisthoughttoarisefromtheinterplaybetweenexcitationandinhibition;however,theconnectivityrulesthatcontributetosynchronizationarestillunknown.WestudiedtheseissuesinhippocampalCA1microcircuitsusingpairedpatchclamprecordingsandrealtimecomputing.Byvirtuallyconnectingamodelinterneuronwithtwopyramidalcells(PCs),wewereabletotesttheimportanceofconnectivityinsynchronizingpyramidalcellactivity.OurresultsshowthatacircuitwithanonreciprocalconnectionbetweenpyramidalcellsandnofeedbackfromPCstothevirtualinterneuronproducedthegreatestlevelofsynchronizationandmutualinformationbetweenPCspikingactivity.Moreover,weinvestigatedtheroleofintrinsicmembranepropertiescontributingtosynchronizationwheretheapplicationofaspecificionchannelblocker,ZD7288dramaticallyimpairedPCsynchronization.Additionally,backgroundsynapticactivity,inparticulararisingfromNMDAreceptors,hasalargeimpactonthesynchronyobservedintheaforementionedcircuit.Ourresultsgivenewinsightstothebasicconnectionparadigmsofmicrocircuitsthatleadtocoordinationandtheformationofassemblies. | pt_BR |
dc.identifier.issn | 1662-5110 | |
dc.identifier.uri | https://repositorio.ufrn.br/jspui/handle/123456789/23330 | |
dc.language | eng | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | hippocampus | pt_BR |
dc.subject | synchronization | pt_BR |
dc.subject | dynamic clamp | pt_BR |
dc.subject | Ih | pt_BR |
dc.subject | AMPA | pt_BR |
dc.subject | NMDA | pt_BR |
dc.title | Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit | pt_BR |
dc.type | article | pt_BR |
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