Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit

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dc.contributor.authorHilscher, Markus M.
dc.contributor.authorLeão, Emelie Katarina Svahn
dc.contributor.authorLeão, Richardson Naves
dc.date.accessioned2017-06-01T12:39:36Z
dc.date.available2017-06-01T12:39:36Z
dc.date.issued2013-07-23
dc.description.resumoSynchronizationamongneuronsisthoughttoarisefromtheinterplaybetweenexcitationandinhibition;however,theconnectivityrulesthatcontributetosynchronizationarestillunknown.WestudiedtheseissuesinhippocampalCA1microcircuitsusingpairedpatchclamprecordingsandrealtimecomputing.Byvirtuallyconnectingamodelinterneuronwithtwopyramidalcells(PCs),wewereabletotesttheimportanceofconnectivityinsynchronizingpyramidalcellactivity.OurresultsshowthatacircuitwithanonreciprocalconnectionbetweenpyramidalcellsandnofeedbackfromPCstothevirtualinterneuronproducedthegreatestlevelofsynchronizationandmutualinformationbetweenPCspikingactivity.Moreover,weinvestigatedtheroleofintrinsicmembranepropertiescontributingtosynchronizationwheretheapplicationofaspecificionchannelblocker,ZD7288dramaticallyimpairedPCsynchronization.Additionally,backgroundsynapticactivity,inparticulararisingfromNMDAreceptors,hasalargeimpactonthesynchronyobservedintheaforementionedcircuit.Ourresultsgivenewinsightstothebasicconnectionparadigmsofmicrocircuitsthatleadtocoordinationandtheformationofassemblies.pt_BR
dc.identifier.issn1662-5110
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23330
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjecthippocampuspt_BR
dc.subjectsynchronizationpt_BR
dc.subjectdynamic clamppt_BR
dc.subjectIhpt_BR
dc.subjectAMPApt_BR
dc.subjectNMDApt_BR
dc.titleSynchronization through nonreciprocal connections in a hybrid hippocampus microcircuitpt_BR
dc.typearticlept_BR

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