What are the mechanisms of action of anti-inflammatory agents in adipose tissue? a protocol for systematic review and meta-analysis

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dc.contributor.authorMorais, Ana Heloneida de Araujo
dc.contributor.authorNascimento, Sara Sayonara da Cruz
dc.contributor.authorQueiroz, Jaluza Luana Carvalho de
dc.contributor.authorMedeiros, Amanda Fernandes de
dc.contributor.authorNunes, Ana Clara de França
dc.contributor.authorPiuvezam, Grasiela
dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorPassos, Thaís Souza
dc.contributor.authorIDhttps://orcid.org/0000-0002-6460-911Xpt_BR
dc.date.accessioned2023-07-31T18:01:27Z
dc.date.available2023-07-31T18:01:27Z
dc.date.issued2021
dc.description.resumoBackground: Obesity is a disease characterized by the abnormal accumulation of adipose tissue in the body, triggering a chronic subclinical state of inflammation. Bioactive compounds, given their anti-inflammatory properties, are a safe and promising alternative in controlling the inflammatory condition of obesity. This study describes a systematic review protocol aiming to analyze the anti inflammatory molecules mechanisms and compounds action on adipocytes. Methods: Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) will outline the protocol and PRISMA to the systematic review. The databases used for research will be PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. Experimental studies performed on rats and mice with a control group that describes treatment with anti-inflammatory agents (drugs, nutraceuticals, bio active compounds, among others) at any frequency, time, and dose will be included. Three independent reviewers will select studies and extract data. The evaluation of the methodological quality of each research will be performed using the SYRCLE tool. If at least 2 studies show clinical and/or methodological and/or statistical homogeneity, a meta analysis will be performed, using the RevMan Analyzes statistical package in Review Manager v.5.3. Results: In this study, we hope to find a considerable number of articles presenting mechanisms involved in the action of anti inflammatory molecules and compounds on adipocytes. Conclusion: The systematic review produced from this protocol will present evidence on the mechanisms involved in the action of anti-inflammatory molecules and compounds in adipocytes. It will also contribute to developing new research and new insights about anti-inflammatory therapies with a future application view. Record of systematic review: This review was registered with the International Register of Prospective Systematic Reviews on May 18, 2020 (registration: CRD42020182897). Available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID= CRD42020182897. Abbreviations: 5-LOX = enzyme 5-lipoxygenase, AMPK = AMP-activated protein kinase, BAT = brown adipose tissue, CAPES = Coordination of Improvement of Higher Education Personnel, CNPq = National Council for Scientific and Technological Development, COX-2 = enzyme cyclooxygenase, IL-6 = Interleukin-6, iNOS = nitric oxide-synthase induced, NF-kB = factor kappa B, Nrf2 = nuclear factor erythroid 2-related factor 2, PICOS = population, interventions, control, and study results, PPAR-g = peroxisome proliferator-activated receptor gamma, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta Analyses, PRISMA-P = Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols, PROSPERO = International Prospective Register of Systematic Reviews, SREBP-1c = sterol regulatory element-binding protein 1, Syrcle = Systematic Review Center for Laboratory Animal Experimentation, TLR = Toll-like receptors, TNF-a = Tumor Necrosis Factor alpha, WAT = white adipose tissue, WHO = World Health Organization.pt_BR
dc.identifier.citationNASCIMENTO, Sara Sayonara da Cruz et al. What are the mechanisms of action of anti-inflammatory agents in adipose tissue?: a protocol for systematic review and meta-analysis. Medicine, v. 100, n. 8, p. e24677-e24677, 2021.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1097/MD.0000000000024677
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54303
dc.languageenpt_BR
dc.publisherMedicinept_BR
dc.subjectAdipose tissuept_BR
dc.subjectanti-inflammatory agentspt_BR
dc.subjectbody fatpt_BR
dc.subjectinflammationpt_BR
dc.subjectobesitypt_BR
dc.subjectsystematic reviewpt_BR
dc.titleWhat are the mechanisms of action of anti-inflammatory agents in adipose tissue? a protocol for systematic review and meta-analysispt_BR
dc.typearticlept_BR

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