Gene mutyh associado à neoplasias malignas com ênfase no câncer de ovário

Abstract

Neoplasms are characterized by the disordered and uncontrollable development of cells in the body, thus materializing malignant neoplasms, in which cells that multiply and have the ability to invade other organs and tissues. Cancer is an ancient disease, identified since the era of Hippocrates, which has grown considerably throughout the world. Genes, therefore, being segments of a DNA molecule, characterized by the presence of a specific DNA sequence containing a code for the production of a protein responsible for certain functions in the body, can undergo changes and trigger the emergence of different types of cancer. The MUTYH gene is a base excision repair enzyme with a fundamental role in correcting DNA errors in guanine oxidation and is also considered a cellular protection factor. The largest number of studies carried out refers to the association between the Mutyh gene and the development of colorectal cancer, being verified that patients with this type of neoplasm have more mutation variants in this gene and the non-functional Mutyh predisposes to carcinogenesis.