Caracterização espectroscópica e termoanalítica de nanoformulações contendo cinamato de pentila: um novo larvicida para o combate ao Aedes aegypti

Abstract

Aedes aegypti is the main vector of diseases such as Dengue, Chikugunya and Zika, making it an important public health problem. The application of chemical pesticides for vector control can affect human health, the environment, in addition to conferring resistance to mosquitoes. Pentyl cinnamate (CP), a derivative of cinnamic acid, showed activity against Aedes aegypti larvae, however, due to its low water solubility, a technological strategy was developed to improve its water solubility. Therefore, the aim of this study was to characterize the solid microparticles incorporated with CP obtained after drying nanoemulsions stabilized with lecithins using the spectroscopic techniques of NMR and IR and Thermal Analysis. In 1H and IR NMR spectroscopy the chemical structure of pentyl cinnamate was characterized by identifying protons at 0.92; 1.41; 1.71; 4.20; 6.44; 7.28; 7.53 and 7.69 ppm and the main functional groups present in the molecule, being in 2750, 1465, 1375, 1630 and 1850 cm-1, respectively. The TG and DSC data showed a greater thermal protection of the CP when it was incorporated into the microparticles. Thus, spectroscopic and thermoanalytical techniques were able to confirm the incorporation and compatibility of pentyl cinnamate to solid microparticles, revealing itself as a promising proposal for a new larvicide to combat Aedes aegypti.