Proteína C Reativa e sua relação com marcadores antropométricos e bioquímicos na predição de alterações cardiovasculares em adolescentes com excesso de peso

Abstract

Introduction: Anthropometric and biochemical parameters help in the classification of risk factors for cardiovascular disease. Among them, C-reactive protein (CRP) is an important biomarker sensitive to the identification of subclinical systemic proinflammatory condition in individuals with obesity. Objective: To analyze anthropometric and biochemical markers and CRP concentrations and their ability to predict cardiovascular changes. Methodology: Cross-sectional study with 184 overweight/obese adolescents aged 10 to 19 years. Anthropometric (height, weight and waist and neck perimeter) and biochemical (lipid, glycemic and CRP concentrations) data were collected. Data were evaluated by Pearson's correlation coefficient tests and Fisher's exact test. Results with p-value < 0.05 were considered statistically significant. Results: Of the 184 adolescents, 52.72% were boys. Girls had higher values for fasting insulin and HOMA-IR, and boys had higher values for waist-to-height ratio. In boys, CRP was positively correlated with body mass index (BMI), waist circumference, fasting insulin (p<0.005) and HOMA-IR (p<0.005) and waist-to-height ratio (p<0.001). And in girls with BMI and waist/height ratio (p<0.005). Conclusion: Anthropometric and glycemic profile markers correlated with CRP concentrations in overweight adolescents, suggesting that CRP can predict cardiovascular risk.