Avaliação do perfil bioquímico de gestantes saudáveis em dois períodos da gestação

Abstract

Introduction: The pregnant state is responsible for metabolic and physiological changes in the female body to support and maintain maternal health during this period. These changes are generally classified as: hematological, cardiac, renal, respiratory, anatomical, endocrine and biochemical. Objective: We aim to evaluate the concentrations of biochemical parameters that reflect the general metabolic condition in two periods (1st and 3rd trimester) of pregnancy of healthy women. Material and Methods: Thirty-four pregnant women were recruited and classified into two groups according to gestational age (> 30 and ≤ 30 weeks). Blood, collected by fasting venipuncture (evaluation of the biochemical profile), and urine (albumin ratio creatinine – RAC) samples were evaluated. Results: The independent t-test showed that, on average, pregnant women with a gestational age greater than 30 weeks (group> 30) have higher values of triglycerides (p = 0.000), VLDL (p = 0.012), ALP (p = 0.003) and uric acid (p = 0.013) and lower, of urea (p = 0.042) and total proteins (p = 0.008) compared to the group ≤ 30. Discussion: The metabolism during the pregnancy state undergoes changes that increase or reduce the values of some biochemical parameters in pregnant women. Changes in the biochemical profile are normal in the natural process of a healthy pregnancy. Conclusion: The present study shows normal physiological changes in the findings of the clinical analyzes of the biochemical parameters used here.