Efeito na fisiologia, e condições hepaticas da curcumina em modelo experimental de mucosite oral

Abstract

Introduction: Oral mucositis is an inflammatory condition of the oral mucosa that may be secondary to radiotherapeutic and chemotherapeutic treatments. Among these, one of the main drugs affecting the oral epithelium is Fluorouracil. At the same time, it is known that mammals can not perform the detoxification of free radicals formed by anti-neoplastic substances, and the literature shows that turmeric has proved to be efficient in capturing these free radicals. in the process of improving periodontitis, gingivitis and other oral conditions. Objectives: To evaluate the anti-inflammatory and hepatotoxic activity in Golden samsung hamsters after administration of curcumin, in the Experimental Model of Oral Mucositis Induced. Methods: 30 animals were used in 6 groups of 5 animals each, distributed in the following groups: normal; trauma; trauma + 5FU; Trauma + 5FU + curcumin 5mg / ml; Trauma + 5FU + curcumin 50mg / ml; Trauma + 5FU + curcumin 100mg / ml. Statistical analysis was by variance (ANOVA) followed by the Bonferroni test to compare means (GraphPad PRISM 5.0 Software). Results: The concentrations of 50mg and 100mg did not present a significant difference in the macroscopic score in relation to the group in which only 5FU, saline (vehicle) after the trauma was administered. Regarding the evaluation of hepatic functions, the groups presented a mean of: 100mg / ml - 62U / L, 50mg / ml - 48U / L and 5mg / ml - 42U / L of TGO. For TGP, the 5mg / ml group of curcumin presented a significant difference in relation to the 100mg / ml group. In the leukocyte counts the mean for the groups were respectively 100mg / ml - 19x103 leukocytes / μL, 50mg / ml - 14x103 leukocytes / μL, while 5mg / ml - 7.45x103 leukocytes / μL. In the basophil count of all groups, the variation remained within the normal range. None of the animals presented eosinophil in a blood sample. Only one animal had monocytes present in the curcumin group 100 mg / ml. Conclusion: At lower concentrations curcumin reduces inflammatory actions and tissue effects caused by 5FU. Higher doses of hepatotoxicity may have caused damage to hepatic cells.