Presence of metalloproteinases 2 and 9 and 8-OHdG in the fibrotic process in skeletal muscle of Mdx mice

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dc.contributor.authorSouza, Lidiane Begalli de
dc.contributor.authorMaziero, Carla
dc.contributor.authorLazzarin, Mariana Cruz
dc.contributor.authorQuintana, Hananiah Tardivo
dc.contributor.authorTomé, Tabata de Carvalho
dc.contributor.authorBaptista, Vivianne Izabelle de Araújo
dc.contributor.authorOliveira, Flavia de
dc.date.accessioned2020-12-21T13:14:33Z
dc.date.available2020-12-21T13:14:33Z
dc.date.issued2020-01
dc.description.resumoInflammation and oxidative stress occurs in muscle of Duchenne muscular dystrophy (DMD). The relationship between a panel of biomarkers and the DMD outcome is necessary to indicate of disease progression and response to rehabilitation programs. The aim was to analyze the connective tissue of muscle of Mdx mice and immunoexpression of MMP-2, MMP-9, and 8-OHdG, which signalizes oxidative stress related to DNA damage. Biceps brachii of male C57BL/10 and C57BL/10-Dmdmdx mice was submitted to Hematoxylin-Eosin, Sirius red and immunohistochemistry (MMP-2, MMP-9 and 8-OHdG) analysis. Mdx showed focal lesions with intense inflammation and fibrosis related to immunoexpression of MMP-2 and MMP-9, proving the hypothesis that these MMPs are linked to muscular tissue degeneration, which can be regenerated by their inhibition, improving the treatment of DMD carriers. Histopathological findings related to centralized nuclei increase were related to higher 8-OHdG immunomarked nuclei in Mdx, which signalizes oxidative stress associated with DNA damage provoked by DMD. Such result shows that the evaluation of 8-OHdG during the evolution of the disease could be a method to evaluate DMD disease progressionpt_BR
dc.identifier.citationSOUZA, Lidiane Begalli de; MAZIERO, Carla; LAZZARIN, Mariana Cruz; QUINTANA, Hananiah Tardivo; TOMÉ, Tabata de Carvalho; BAPTISTA, Vivianne Izabelle de Araújo; OLIVEIRA, Flavia de. Presence of metalloproteinases 2 and 9 and 8-OHdG in the fibrotic process in skeletal muscle of Mdx mice. Acta Histochemica, [s. l.], v. 122, n. 1, p. 1-5, jan. 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S0065128119301801?via%3Dihub. Acesso em: 03 nov. 2020. http://dx.doi.org/10.1016/j.acthis.2019.151458pt_BR
dc.identifier.doi10.1016/j.acthis.2019.151458
dc.identifier.issn0065-1281
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/31073
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectDuchenne muscular dystrophypt_BR
dc.subjectSkeletal musclept_BR
dc.subjectMMP-2pt_BR
dc.subjectMMP-9pt_BR
dc.subject8-OHdGpt_BR
dc.titlePresence of metalloproteinases 2 and 9 and 8-OHdG in the fibrotic process in skeletal muscle of Mdx micept_BR
dc.typearticlept_BR

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