Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography

Souza Júnior, José Edvan de; Garcia, Carlos Alexandre de Amorim; Soares, Elvira Maria Mafaldo; Maranhão, Técia Maria Oliveira; Lemos, Telma Maria Araujo Moura; Azevedo, George Dantas de

Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography

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dc.contributor.author	Souza Júnior, José Edvan de
dc.contributor.author	Garcia, Carlos Alexandre de Amorim
dc.contributor.author	Soares, Elvira Maria Mafaldo
dc.contributor.author	Maranhão, Técia Maria Oliveira
dc.contributor.author	Lemos, Telma Maria Araujo Moura
dc.contributor.author	Azevedo, George Dantas de
dc.date.accessioned	2021-02-19T17:02:20Z
dc.date.available	2021-02-19T17:02:20Z
dc.date.issued	2015-02-11
dc.description.resumo	Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measurement of MT, RNFL, and optic disc parameters using optical coherence tomography. Results. The superior RNFL around the optic nerve was significantly thicker in PCOS than in healthy volunteers (𝑃 = 0.036). After stratification according to insulin resistance, the temporal inner macula (TIM), the inferior inner macula (IIM), the nasal inner macula (NIM), and the nasal outer macula (NOM) were significantly thicker in PCOS group than in control group (𝑃 < 0.05). Both the presence of obesity associated with insulin resistance (𝑃 = 0.037) and glucose intolerance (𝑃 = 0.001) were associated with significant increase in the PC1 mean score, relative to MT. A significant increase in the PC2 mean score occurred when considering the presence of metabolic syndrome (𝑃 < 0.0001). There was a significant interaction between obesity and inflammation in a decreasing mean PC2 score relative to macular RNFL thickness (𝑃 = 0.034). Conclusion. Decreased macular RNFL thickness and increased total MT are associated with metabolic abnormalities, while increased RNFL thickness around the optic nerve is associated with hormonal changes inherent in PCOS	pt_BR
dc.identifier.citation	SOUZA JÚNIOR, José Edvan de; GARCIA, Carlos Alexandre de Amorim; SOARES, Elvira Maria Mafaldo; MARANHÃO, Técia Maria Oliveira; LEMOS, Telma Maria Araújo Moura; AZEVEDO, George Dantas de. Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography. Journal Of Ophthalmology, [s. l.], v. 2015, p. 1-8, 2015. Disponível em: https://www.hindawi.com/journals/joph/2015/193078/. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1155/2015/193078	pt_BR
dc.identifier.doi	10.1155/2015/193078
dc.identifier.issn	2090-004X
dc.identifier.issn	2090-0058
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31564
dc.language	en	pt_BR
dc.publisher	Hindawi	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Polycystic Ovary Syndrome	pt_BR
dc.subject	Optical Coherence Tomography	pt_BR
dc.subject	Ophthalmology	pt_BR
dc.subject	Macular Thickness	pt_BR
dc.subject	Retinal Nerve Fiber Layers	pt_BR
dc.title	Polycystic Ovary Syndrome: aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography	pt_BR
dc.type	article	pt_BR