mTOR inhibition impairs extinction memory reconsolidation
| Author | Radiske, Andressa; Gonzalez, Maria Carolina; Ferreira, Diana Aline Nôga Morais; Rossato, Janine Inez; Bevilaqua, Lia Rejane Müller; Cammarota, Martín Pablo | |
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| Publisher | Cold Spring Harbor Laboratory | |
| Date | 2020-12-15 | |
| Keywords | Memory reconsolidation Brain-derived neurotrophic factor BDNF TOR Serine-threonine kinases Mammalian target of rapamycin | |
| Citation | ||
| Abstract | Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence and recovers the learned aversive response. Importantly, coadministration of recombinant BDNF impedes the behavioral effect of hippocampal mTOR inhibition. Our results demonstrate that mTOR signaling is necessary for fear-motivated avoidance extinction memory reconsolidation and suggests that BDNF acts downstream mTOR in a protein synthesis-independent manner to maintain the reactivated extinction memory trace | |
| URI | https://repositorio.ufrn.br/handle/123456789/31230 | |
| Collections | ICe - Artigos publicados em periódicos |
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