Early life adversity and C-reactive protein in diverse populations of older adults: a cross-sectional analysis from the International Mobility in Aging Study (IMIAS)

Li, Annie; Tu, Mai Thanh; Sousa, Ana Carolina Patricio de Albuquerque; Alvarado, Beatriz; Kone, Georges Karna; Guralnik, Jack; Zunzunegui, Maria Victoria

Early life adversity and C-reactive protein in diverse populations of older adults: a cross-sectional analysis from the International Mobility in Aging Study (IMIAS)

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dc.contributor.author	Li, Annie
dc.contributor.author	Tu, Mai Thanh
dc.contributor.author	Sousa, Ana Carolina Patricio de Albuquerque
dc.contributor.author	Alvarado, Beatriz
dc.contributor.author	Kone, Georges Karna
dc.contributor.author	Guralnik, Jack
dc.contributor.author	Zunzunegui, Maria Victoria
dc.date.accessioned	2021-01-05T16:18:37Z
dc.date.available	2021-01-05T16:18:37Z
dc.date.issued	2015-08-19
dc.description.resumo	Background: Recent studies suggest potential associations between childhood adversity and chronic inflammation at older ages. Our aim is to compare associations between childhood health, social and economic adversity and high sensitivity C-reactive protein (hsCRP) in populations of older adults living in different countries. Methods: We used the 2012 baseline data (n = 1340) from the International Mobility in Aging Study (IMIAS) of community-dwelling people aged 65–74 years in Natal (Brazil), Manizales (Colombia) and Canada (Kingston, Ontario; Saint-Hyacinthe, Quebec). Multiple linear and Poisson regressions with robust covariance were fitted to examine the associations between early life health, social, and economic adversity and hsCRP, controlling for age, sex, financial strain, marital status, physical activity, smoking and chronic conditions both in the Canadian and in the Latin American samples. Results: Participants from Canadian cities have less adverse childhood conditions and better childhood self-reported health. Inflammation was lower in the Canadian cities than in Manizales and Natal. Significant associations were found between hsCRP and childhood social adversity in the Canadian but not in the Latin American samples. Among Canadian older adults, the fully-adjusted mean hsCRP was 2.2 (95 % CI 1.7; 2.8) among those with none or one childhood social adversity compared with 2.8 (95 % CI 2.1; 3.8) for those with two or more childhood social adversities (p = 0.053). Similarly, the prevalence of hsCRP > 3 mg/dL was 40 % higher among those with higher childhood social adversity but after adjustment by health behaviors and chronic conditions the association was attenuated. No associations were observed between hsCRP and childhood poor health or childhood economic adversity. Conclusions: Inflammation was higher in older participants living in the Latin American cities compared with their Canadian counterparts. Childhood social adversity, not childhood economic adversity or poor health during childhood, was an independent predictor of chronic inflammation in old age in the Canadian sample. Selective survival could possibly explain the lack of association between social adversity and hsCRP in the Latin American samples	pt_BR
dc.identifier.citation	LI, Annie; TU, Mai Thanh; SOUSA, Ana Carolina Patrício de Albuquerque; ALVARADO, Beatriz; KONE, Georges Karna; GURALNIK, Jack; ZUNZUNEGUI, Maria Victoria. Early life adversity and C-reactive protein in diverse populations of older adults: a cross-sectional analysis from the International Mobility in Aging Study (IMIAS). Bmc Geriatrics, [s. l.], v. 15, n. 1, p. 102, 19 ago. 2015. Springer Science and Business Media LLC. Disponível em: https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-015-0104-2. Acesso em: 18 ago. 2020. http://dx.doi.org/10.1186/s12877-015-0104-2.	pt_BR
dc.identifier.doi	10.1186/s12877-015-0104-2
dc.identifier.issn	1471-2318 (online)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31187
dc.language	en	pt_BR
dc.publisher	BMC	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Aging, physiology	pt_BR
dc.subject	C-Reactive Protein, analysis	pt_BR
dc.subject	Chronic Disease	pt_BR
dc.subject	Cross-Sectional Studies	pt_BR
dc.subject	Prevalence	pt_BR
dc.subject	Child Health	pt_BR
dc.title	Early life adversity and C-reactive protein in diverse populations of older adults: a cross-sectional analysis from the International Mobility in Aging Study (IMIAS)	pt_BR
dc.type	article	pt_BR