Manipulação de ansiedade induzida por ruído alto mediante a hiperexpressão de canais KV1.2

Abstract

Tinnitus is a condition characterized by the perception of sound unilaterally or bilaterally in the absence of any external stimuli. It is one of the most common otological problems and is strongly associated with emotional distress, such as depression and anxiety. Tinnitus induction is a condition that tends to cause distress and is related to changes in behavioral traits. In this study, we demonstrate the anxious behavioral potential of mice exposed to tinnitus and propose the manipulation of the anxiety response caused by chronic tinnitus in mice through the hyperexpression de Kv1.2 channels. Here, we explore the role of the amygdala and Kv1.2 potassium channels to establish the theoretical basis for future studies. We focus on the experimental foundations of an anxious animal model induced by high-intensity noise tinnitus and its behavioral patterns, as evidenced by tests in the elevated plus maze and circular open field. This study represents the beginning of a larger investigation aimed at understanding the manipulation of anxiety and the role of voltage-sensitive potassium channels through behavioral analysis in mice.